摘要
目的分析无锡市梁溪区艾滋病病毒感染者/艾滋病病人(HIV/AIDS)确证后生存时间及影响因素。方法运用回顾性队列研究方法,对2002—2019年无锡市梁溪区新报告的HIV/AIDS,采用寿命表法计算生存率,采用Kaplan-Meier法和Cox比例风险模型分析生存时间的影响因素。结果共纳入HIV/AIDS 845例,89例(10.5%)因艾滋病及相关疾病死亡。平均生存时间为14.17年(95%CI:13.73~14.61),1、5、10年生存率分别为93.4%、89.9%、84.2%。多因素Cox比例风险模型分析显示:诊断时年龄≥50岁(HR=2.60,95%CI:1.28~5.27),疾病状态为AIDS(HR=3.40,95%CI:2.01~5.76),样本来源为医疗机构(HR=2.50,95%CI:1.32~4.76),未接受抗病毒治疗(HR=34.92,95%CI:18.38~66.37),首次CD4^+T淋巴细胞计数<350/μl(HR=2.65,95%CI:1.25~5.63)为HIV/AIDS死亡的危险因素(P值均<0.05)。结论无锡市梁溪区HIV/AIDS诊断后平均生存时间较长,仍需进一步加大HIV主动筛查力度,早检测、早发现、早治疗,降低患者死亡风险。
Objective To analyze the survival time of HIV/AIDS patients and its influencing factors in Liangxi district of Wuxi city.Methods A retrospective cohort study was conducted to analyze newly reported HIV/AIDS patients in Liangxi district,the life table method was used to calculate the survival rate while Kaplan Meier method and Cox proportion hazard regression model were used to identify the influencing factors related to survival time.Results A total of 845 HIV/AIDS patients were included for study,among whom 89(10.5%)died of AIDS related diseases.The mean survival time was 14.17(95%CI:13.73-14.61)years.The 1-,5-and 10-year survival rates were 93.4%,89.9%,and 84.2%,respectively.Multivariate Cox regression analysis showed that diagnosis age≥50 years(HR=2.60,95%CI:1.28-5.27),disease status at diagnosis of AIDS(HR=3.40,95%CI:2.01-5.76),samples from medical institutions(HR=2.50,95%CI:1.32-4.76),not receiving antiretroviral therapy(ART)(HR=34.92,95%CI:18.38-66.37);the first CD4^+T cell counts<350/μl(HR=2.65,95%CI:1.25-5.63)were risk factors for death of HIV/AIDS patients(all P<0.05).Conclusion The average survival time after diagnosis of HIV/AIDS patients in Liangxi district was relatively long.It is necessary to further strengthen active HIV screening,early detection and early treatment to reduce the death risk of HIV/AIDS patients.
作者
庄梅珠
许爱玲
ZHUANG Mei-zhu;XU Ai-ling(Liangxi District Centre for Disease Control and Prevention,Jiangsu Wuxi 214000,China)
出处
《江苏预防医学》
CAS
2020年第4期359-362,共4页
Jiangsu Journal of Preventive Medicine
关键词
艾滋病
回顾性研究
生存分析
影响因素
AIDS
Retrospective study
Survival analysis
Influencing factor
