摘要
将自组装多肽/海藻酸钠与氯化钙反应,利用水动力学拉伸收集,得到平行排列的活性微凝胶纤维;利用聚电解质反应制备壳聚糖/海藻酸钙/自组装多肽微凝胶纤维,并通过溶胀率分析、扫描电子显微镜观察、细胞毒性检测、支架与神经干细胞的相互作用评价该复合微凝胶纤维对神经再生的作用。结果表明,壳聚糖/海藻酸钙/自组装多肽微凝胶纤维高度规整,平行,生物相容性良好,能够支持神经干细胞的生长和分化并能引导神经轴突的定向生长。
A functional self-assembling peptide/sodium alginate reacted with calcium chloride to obtain a parallel active hydrogel microfibers by the hydrodynamic stretching,then the chitosan/calcium alginate/self-assembling peptide hydrogel microfibers are obtained through polyelectrolyte composite reaction.The application of the nanocomposite scaffolds in nerve regeneration is studied by SEM,cytotoxicity,the interaction between the matrixt and the neural stem cells.The results show that the nanocomposite scaffolds are highly regular and parallel and have good biocompatibility.Besides,the nanocomposite scaffolds can support the growth and differentiation of neural stem cells and can guide the directional growth of axons.
作者
胡萍
张双英
李洁
雷琪琪
张文柠
敖宁建
HU Ping;ZHANG Shuang-ying;LI Ji;LEI Qi-qi;ZHANG Wen-ning;AO Ning-jian(College of Life Science And Technology,Jinan University,Guangzhou 510632,China;Key Laboratory of Biomaterials,Education Department of Guangdong Province,Guangzhou 510632,China)
出处
《高分子通报》
CAS
CSCD
北大核心
2020年第8期49-54,共6页
Polymer Bulletin
基金
国家自然科学基金资助项目(20976068)。
关键词
微凝胶纤维
自组装多肽
海藻酸钠
壳聚糖
神经修复
Hydrogel microfibers
Self-assembling peptide
Sodium alginate
Chitosan
Nerve repair
