摘要
目的通过动态检查潮气呼吸肺功能及检测炎症因子浓度评估慢性咳嗽或反复喘息婴幼儿家庭雾化的疗效。方法选择门诊因慢性咳嗽或反复喘息(病程超过1个月)的婴幼儿100例,家长愿意在进行家庭雾化前后进行潮气呼吸肺功能检测的65例设为观察组,家长不愿意的35例作为对照组。所有患儿监测治疗后咳嗽和/或喘息消失时间、雾化治疗总天数、治疗后6月内呼吸道感染次数、治疗后1年内呼吸道感染次数、治疗前后潮气呼吸肺功能相关指标、治疗前后炎症因子浓度变化。结果治疗1年内调查发现,观察组家庭雾化总天数明显多于对照组,反复出现呼吸道感染次数均少于对照组,观察组治疗后1个月、6个月后达峰时间比及达峰容积比改善情况明显优于对照组;治疗3个月后观察组炎症因子IL-4、IL-6及TNF-a血清浓度明显下降,与对照组相比,差异均有统计学意义(P<0.05)。随着患儿气道阻塞程度改善,炎症因子浓度也同步下降。结论定期监测潮气呼吸肺功能及炎症因子血清浓度可指导家庭雾化治疗疗程,有助于改善患儿预后;患儿气道阻塞程度与炎症因子浓度呈正相关。
Objective To evaluate the therapeutic effect of family atomization in infants with chronic cough or recurrent wheezing by dynamic examination of tidal respiratory and pulmonary function and detection of inflammatory factor concentration.Methods Choose 100 infants and young children who have chronic cough or repeated wheezing(the course of disease exceeds 1 month)in the outpatient clinic.65 cases whose parents are willing to perform tidal breathing and lung function tests before and after home nebulization are set as the observation group,and 35 cases whose parents are unwilling are taken as Control group.All children monitored the disappearance time of cough and/or wheezing after treatment,the total number of days of nebulization treatment,the number of respiratory infections within 6 months after treatment,the number of respiratory infections within 1 year after treatment,tidal respiratory and lung function related indicators before and after treatment,and inflammatory factors before and after treatment Concentration changes.Results An investigation within 1 year of treatment found that the total number of days of household nebulization in the observation group was significantly more than that of the control group,and the number of recurrent respiratory infections was less than that of the control group.The peak time ratio and peak volume of the observation group 1 month and 6 months after treatment The improvement was significantly better than that of the control group;after 3 months of treatment,the serum concentrations of inflammatory factors IL-4,IL-6 and TNF-a in the observation group were significantly reduced,and compared with the control group,the difference was statistically significant(P<0.05).As the degree of airway obstruction in children improves,the concentration of inflammatory factors also decreases.Conclusion Regular monitoring tidal breathing pulmonary function and serum concentration of inflammatory factors can guide the course of family aerosol therapy,it is helpful to improve the prognosis o
作者
巫斌
黄从付
李秀云
汪培勤
熊升华
伍根峰
彭思萍
WU Bin;HUANG Congfu;LI Xiuyun;WANG Peiqin;XIONG Shenghua;WU GenFeng;PENG Siping(Maternal and Child Health Hospital of Longgang District,Shenzhen,Shenzhen 518172,China;不详)
出处
《现代医院》
2020年第9期1378-1381,共4页
Modern Hospitals
基金
深圳市龙岗区科技创新计划项目(20170401092156170)。
关键词
潮气呼吸肺功能
炎症因子
家庭雾化治疗
婴幼儿
Tidal breathing pulmonary function
Inflammatory factor
Family aerosol therapy
Infants
