摘要
目的:研究癫痫患者的性别、年龄、体重、联合用药及合并疾病对丙戊酸血清浓度/剂量比(concentration/dose,C/D)的影响。方法:回顾性分析2018年5月至2019年8月某院进行丙戊酸血清浓度监测的癫痫患者77例,将性别、年龄、体重、联合用药、合并疾病、日剂量和血清药物浓度等信息录入Excel表,计算C/D值,采用SPSS 22.0软件进行统计分析。结果:年龄<6岁、6~<12岁、12~<18岁、18~<60岁及≥60岁患者的丙戊酸C/D分别为(192.80±106.44)、(113.37±53.36)、(64.77±33.67)(60.34±23.82)及(84.80±21.50)ng·d/(mg·ml),差异有统计学意义(P<0.05)。体重<22 kg、22~35 kg及>35 kg患者的丙戊酸C/D分别为(176.41±114.75)、(134.61±43.76)及(63.12±27.26)ng·d/(mg·ml),差异有统计学意义(P<0.05)。而性别、联合用药及合并疾病对丙戊酸C/D无影响。结论:<12岁(尤其<6岁)的儿童以及体重≤35 kg的患者,需适当减少丙戊酸剂量,谨防发生不良反应。
OBJECTIVE:To investigate the effects of gender,age,weight,drug combination and concomitant disease on serum drug concentration/dose ratio(C/D)of valproic acid in patients with epilepsy.METHOD:77 patients with epilepsy who were monitored for serum drug concentration of valproic acid in a certain hospital from May 2018 to Aug.2019 were retrospectively analyzed.Information including gender,age,weight,drug combination,concomitant disease,daily dose and serum drug concentration were entered into the Excel table to calculate C/D values.SPSS 22.0 was adopted to conduct statistical analysis.RESULTS:The C/D values of patients aged<6 years,6-<12 years,12-<18 years,18-<60 years,≥60 years were respectively(192.80±106.44),(113.37±53.36),(64.77±33.67),(60.34±23.82)and(84.80±21.50)ng·d/(mg·ml),with statistically significant differences(P<0.05).The C/D values of patients weighed<22 kg,22-35 kg and>35 kg were respectively(176.41±114.75),(134.61±43.76)and(63.12±27.26)ng·d/(mg·ml),with statistically significant differences(P<0.05).Gender,drug combination and concomitant disease had no effects on the C/D values.CONCLUSIONS:Children age<12 years old(especially<6 years old)and patients weighed≤35 kg need to reduce the dose of valproic acid appropriately to prevent adverse drug reactions.
作者
曾晓云
林子琦
葛冰琛
阙富昌
周本杰
ZENG Xiaoyun;LIN Ziqi;GE Bingchen;QUE Fuchang;ZHOU Benjie(Dept. of Pharmacy, the Seventh Affiliated Hospital of Sun Yat-sen University, Guangdong Shenzhen 518107, China;School of Pharmacy, Guangdong Medical University, Guangdong Dongguan 523808, China)
出处
《中国医院用药评价与分析》
2020年第8期914-916,919,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
广东省医院药学研究基金(No.2019A01)。
关键词
丙戊酸
血清药物浓度/剂量比
影响因素
年龄
体重
Valproic acid
Serum drug concentration/dose ratio
Influencing factor
Age
Weight
