摘要
目的 评估抑郁症患儿体内盐酸舍曲林血浆谷浓度的分布特征和影响因素。方法 采用液相色谱-质谱联用技术测定2022年1月—2023年11月期间服用盐酸舍曲林的119例抑郁症患者儿的血浆谷浓度,分析盐酸舍曲林血浆谷浓度的分布特征和影响因素。结果 119例患儿中14例患儿的盐酸舍曲林血浆谷浓度<10 ng·mL^(-1),105例患儿盐酸舍曲林谷浓度在有效血药浓度范围内(10~150 ng·mL^(-1))。患儿的盐酸舍曲林给药剂量与血浆谷浓度呈正相关,但相关性较差(r=0.223,P<0.05)。男性患儿的盐酸舍曲林血浆谷浓度剂量比(CDR)值显著高于女性患儿(t=-2.399,P<0.05);汉族患儿的盐酸舍曲林CDR值显著高于维吾尔族患儿(t=2.505,P<0.05);身体质量指数(BMI)>24.0 kg·m^(-2)患儿的盐酸舍曲林CDR值显著高于BMI<18.5 kg·m^(-2)和18.5 kg·m^(-2)≤BMI≤24.0 kg·m^(-2)患儿(F=15.345,P<0.05)。结论 盐酸舍曲林血浆谷浓度在抑郁症患儿中的个体差异大,性别、民族和BMI可能影响盐酸舍曲林血浆谷浓度。
Objective To evaluate the distribution characteristics and influencing factors of sertraline trough concentration in patients with depression in Xinjiang.Methods Liquid chromatography-mass spectrometry(LC-MS)was used to determine the plasma trough concentrations of 119 patients with depression who took sertraline from January 2022 to November 2023,and the distribution characteristics and influencing factors of sertraline trough concentrations were analyzed.Results Among the 119 children,the plasma trough concentration of sertraline<10 ng·mL^(-1),and the trough concentration of sertraline in 105 children was within the therapeutic concentration range(10—150 ng·mL^(-1)).The dose of sertraline administered was positively correlated with the plasma trough concentration,but the correlation was poor(r=0.223,P<0.05).The concentration to dose ratio(CDR)value of sertraline in male children was significantly higher than that of female children(t=-2.399,P<0.05),the CDR value of sertraline in Han children was significantly higher than that of Uygur children(t=2.505,P<0.05),and the CDR value of sertraline in children with body mass index(BMI)>24.0 kg·m^(-2) was significantly higher than that of children with BMI<18.5 kg·m^(-2) and 18.5 kg·m^(-2)≤BMI≤24.0 kg·m^(-2)(F=15.345,P<0.05).Conclusion The trough plasma concentration of sertraline varies widely among children with depression,and gender,ethnicity,and BMI may affect the trough plasma concentration of sertraline.
作者
张惠兰
王磊
赵婷
李红健
于鲁海
ZHANG Huilan;WANG Lei;ZHAO Ting;LI Hongjian;YU Luhai(Department of Pharmacy,Institute of Clinical Pharmacy of Xinjing Uygur Autonomous Region,People's Hospital of Xinjing Uygur Autonomous Region,Urumqi 830000,China;Department of Respiratory and Critical Care Medicine,Qingdao Third People's Hospital,Qingdao 266000,China)
出处
《药物评价研究》
CAS
北大核心
2024年第7期1619-1623,共5页
Drug Evaluation Research
基金
新疆维吾尔自治区人民医院科研基金资助项目(20220214)。
关键词
盐酸舍曲林
患儿
抑郁症
血浆谷浓度
影响因素
sertraline
pediatric patients
depression
trough plasma concentration
influencing factors
