摘要
目的:探讨阿立哌唑与奥氮平对精神分裂症患者血清催乳素水平、体质量、血糖、血脂等相关因素的影响。方法:将120例精神分裂症患者随机分为研究组(阿立哌唑系统治疗)与对照组(奥氮平系统治疗),共治疗8周,于基线、治疗第4周末和第8周末分别对患者的催乳素、血糖、血脂进行测定。结果:在治疗4周末和8周末研究组患者的催乳素、体质量、血糖、血脂与基线明显升高,差异有统计学意义(P>0.05),对照组患者在第4周末和8周末的催乳素、体质量较基线明显升高,差异有统计学意义(P<0.05)。两组患者的催乳素在第4周末和8周末相比,均具有非常显著的统计学差异(P<0.01)。结论:阿立哌唑对精神分裂症患者的催乳素、体质量无明显影响,而奥氮平对催乳素、体质量有一定影响,两者对血糖、血脂均无明显影响。
Objective：To study the influence of Arpriazole and Olazpine on serum prolactin,body weight,blood sugar and blood lipid of schizophrenic patients.Methods：A total of 120 patients with schizophrenia were randomly divided into study group with Arpriazole and control group with Olazpine for treatment of 8 weeks.They were determined respectively for serum prolactin,body weight,blood sugar and blood lipid in baseline,the 4th weekend and 8th weekend.Results： In the 4th weekend and 8th weekend after treatment,there were no differences for serum prolactin,body weight,blood sugar and blood lipid in study group compared with the baseline.But in the 4th weekend and 8th weekend after treatment,the serum prolacetin and body weight in control group were both significantly higher than those in baseline（P〈0.05）.There had significant differences for serum prolactin between two groups in the 4th weekend and 8th weekend（P〈0.05）.Conclusions： Arpriazole has no effects on serum prolactin,body weight of patients with schizophrenia,but Olazpine has significant effects on serum prolactin and body weight.Two drugs have no effects on blood sugar and blood lipid.
出处
《中国民康医学》
2011年第11期1317-1319,共3页
Medical Journal of Chinese People’s Health
关键词
催乳素
体质量
血糖
血脂
阿立哌唑
奥氮平
Serum prolactin； Body weight； Blood sugar； Blood lipid； Arpriazole； Olazpine；
