摘要
目的探讨呼出气一氧化氮(FeNO)及潮气肺功能检测对不同进展期婴幼儿喘息性肺炎的诊断价值。方法选取2018年3月至2019年2月在西安市中心医院儿科接受治疗的131例喘息性支气管肺炎婴幼儿为观察组,选取同期在我院体检的128例健康婴幼儿为对照组,比较对照组及观察组急性期、缓解期婴幼儿的FeNO及潮气肺功能指标,包括达峰时间比(TPTEF/TE)、达峰容积比(VPEF/VE)、每千克体质量潮气量(VT/kg)、吸呼比(TI/TE)、呼吸频率(RR)、25%、50%潮气量时呼气流速(TEF25%、TEF50%)。结果观察组急性期婴幼儿的FeNO浓度为(48.72±16.24)ppb,明显高于对照组的(12.38±4.12)ppb及缓解期的(21.34±7.11)ppb,差异均有显著统计学意义(P<0.01);观察组急性期婴幼儿的TPTEF/TE为(23.72±7.93)%、VPEF/VE为(26.69±8.91)%、VT/kg为(6.91±2.30)mL/kg、TI/TE为0.63±0.21、TEF25%为(85.43±28.51)mL/s及TEF50%为(114.82±38.27)mL/s,均明显低于对照组[(32.24±10.75)%、(36.57±12.19)%、(7.73±2.58)mL/kg、0.78±0.26、(104.37±34.79)mL/s、(127.06±42.35)mL/s]及缓解期[(29.13±9.71)%、(32.46±10.82)%、(9.48±3.16)mL/kg、0.91±0.30、(96.12±32.04)mL/s、(133.01±44.3)mL/s],差异均有统计学意义(P<0.05);而观察组急性期RR为(34.61±11.5)次/分,明显高于对照组的(28.24±9.41)次/分及缓解期的(30.05±10.02)次/分,差异均有统计学意义(P均<0.05);观察组缓解期婴幼儿TPTEF/TE、VPEF/VE、TEF25%水平均较对照组有明显降低,VT/kg、TI/TE则有明显升高,差异具有统计学意义(P均<0.05);Pearson分析结果显示,FeNO浓度与VT/kg呈明显负相关(r=-0.290,P<0.01)。结论潮气通气肺功能及FeNO浓度能判断喘息性肺炎婴幼儿肺炎进展及气道损伤程度,可为临床治疗喘息性肺炎提供参考依据。
Objective To explore the diagnostic value of fractional exhaled nitric oxide (FeNO) and tidal lung function in infants with wheezing pneumonia at different stages. Methods A total of 131 infants with wheezing bronchopneumonia, who admitted to Department of Pediatrics, the Central Hospital of Xi'an City from March 2018 to February 2019, were selected as the observation group. In the same period, 128 healthy infants who underwent physical examination were selected as the control group. The indexes of FeNO and tidal lung function in the acute phase and remission phase in the control group and the observation group were compared, including peak time ratio (TPTEF/TE), peak volume ratio (VPEF/VE), tidal volume per kilogram body weight (VT/kg), inspiratory ratio (TI/TE), respiratory rate (RR), 25%, 50% tidal expiratory flow (TEF25%, TEF50%). Results The FeNO concentration in the acute phase of the observation group was (48.72±16.24) ppb, which was significantly higher than (12.38±4.12) ppb of the control group and (21.34±7.11) ppb in the remission period (all P<0.01). TPTEF/TE, VPEF/VE, VT/kg, TI/TE, TEF25% and TEF50% in the observation group were (23.72±7.93)%,(26.69±8.91)%,(6.91±2.30) mL/kg,(0.63±0.21),(85.43±28.51) mL/s and (114.82±38.27) mL/s, respectively, which were significantly lower than corresponding (32.24±10.75)%,(36.57±12.19)%,(7.73±2.58) mL/kg, 0.78±0.26,(104.37±34.79) mL/s,(127.06±42.35) mL/s of the control group and corresponding (29.13±9.71)%,(32.46±10.82)%,(9.48 ±3.16) mL/kg, 0.91 ±0.30,(96.12±32.04) mL/s,(133.01±44.3) mL/s in remission stage T (all P<0.05). RR in the observation group was (34.61 ± 11.5) times/min, which was significantly higher than (28.24±9.41) times/min in the control group and (30.05±10.02) times/min in remission stage (all P<0.05). The level of TPTEF/TE, VPEF/VE, TEF25% in the observation group was significantly lower than those in the control group, while the level of VT/kg, TI/TE in the observation group was significantly higher than those in the control
作者
景芳丽
王栋
秦艳妮
JING Fang-li;WANG Dong;QIN Yan-ni(Department of Pediatrics,the Central Hospital of Xi'an City,Xi'an 710001,Shaanxi,CHINA)
出处
《海南医学》
CAS
2019年第15期1953-1955,共3页
Hainan Medical Journal
关键词
婴幼儿
喘息性肺炎
急性期
缓解期
呼出气一氧化氮
潮气肺功能
Infants and young children
Asthmatic pneumonia
Acute phase
Remission stage
Fractional exhaled nitric oxide (FeNO)
Tidal pulmonary function
