摘要
目的:探究翁连解毒汤治疗浊毒内蕴型溃疡性结肠炎(Ulcerative Colitis,UC)临床疗效及可能的作用机制。方法:选取2016年2月至2018年12月在攀枝花学院附属医院收治的浊毒内蕴型UC患者130例作为研究对象,按照入院先后顺序分为对照组和观察组,每组65例。对照组常规西医治疗,观察组加用翁连解毒汤,观察2组治疗前、完成治疗后T细胞、NK细胞、炎性反应因子、凝血功能、生命质量变化,完成治疗后总结疗效。结果:观察组患者在NK细胞、T淋巴细胞组成、CR、TNF-α、IL-1β、ESR、内毒素、IL-10、FIB、PLT、APTT改善方面的效果较对照组更优,组间差异有统计学意义(P<0.05)。观察组患者完成治疗后的生命质量量表各维度评分及总评分改善效果优于对照组患者(P<0.05),且临床总有效率和组织病理学疗效率均高于对照组患者(P<0.05)。结论:翁连解毒汤能抑制浊毒内蕴型UC炎性反应,改善高凝状态,提高机体免疫功能,从而提高疗效和生命质量。
Objective:To explore the therapeutic effects and possible mechanism of Wenglian Jiedu Decoction in treating ulcerative colitis(UC)with turbid toxin intrinsic type.Methods:A total of 130 UC patients with turbid toxin intrinsic type admitted to the Affiliated Hospital of Panzhihua College from February 2016 to December 2018 were selected as the research objects,and were divided into a control group and an observation group,with 65 cases in each group according to the order of admission.The control group was treated with Western medicine and the observation group was supplemented with Wenglian Jiedu Decoction based on the control group.The changes of T cells,NK cells,inflammatory factors,coagulation function,and quality of life were observed before and after treatment in the 2 groups.Results:The improvement of NK cells,T lymphocyte composition,CR,TNF-α,IL-1β,ESR,endotoxin,IL-10,FIB,PLT,APTT in the observation group were better than those in the control group,and the differences between groups were statistically significant(P<0.05).The improvement of the quality of life scale dimensional scores and total scores in the observation group was higher than that in the control group(P<0.05),and the total clinical effective rate and histopathological therapeutic effects rate were significantly higher than that in the control group(P<0.05).Conclusion:Wenglian Jiedu Decoction can inhibit UC inflammatory reaction of turbid toxin intrinsic type,improve the hypercoagulable state,improve the body′s immune function,and thus improve the quality of life and therapeutic effects.
作者
罗成福
刘姝
冯燕
李柳
LUO Chengfu;LIU Shu;FENG Yan;LI Liu(Department of Digestion,the Affiliated Hospital of Sichuan Panzhihua College,Panzhihua 617000,China)
出处
《世界中医药》
CAS
2020年第17期2620-2624,共5页
World Chinese Medicine
基金
四川省卫生和计划生育委员会科研课题(16PJ446)。
关键词
翁连解毒汤
浊毒内蕴型
溃疡性结肠炎
T细胞亚群
自然杀伤细胞
炎性反应因子
凝血功能
炎症性肠病评价量表
Wenglian Jiedu Decoction
Turbid toxin intrinsic type
Ulcerative colitis
T cell subsets
Natural killer cells
Inflammatory factors
Coagulation function
Inflammatory bowel disease evaluation scale
