摘要
目的分析微波消融术(MWA)治疗甲状腺良性结节的临床疗效及对患者血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、促甲状腺激素(TSH)水平的影响。方法选取2017年6月~2019年5月成都医学院第一附属医院、四川大学华西医院及西部战区总医院收治的102例甲状腺良性结节患者为研究对象,随机分为观察组(n=51)与对照组(n=51),观察组行MWA,对照组行甲状腺结节切除术。比较两组手术情况,记录观察组术后6个月内结节消退情况,比较两组治疗前后甲状腺功能(T3、T4及TSH)及并发症发生率。结果观察组手术时间、术后住院时间短于对照组(P<0.05);术后,观察组甲状腺结节体积不断缩小(P<0.05),且3、6个月甲状腺结节体积缩小率分别为30.45%、79.70%;治疗后,两组T3、T4下降,TSH水平增加,且观察组治疗后血清T3、T4低于对照组,TSH水平明显高于对照组(均P<0.05);观察组并发症发生率较对照组低(P<0.05)。结论MWA治疗甲状腺良性结节疗效较好,可有效保留患者甲状腺功能,促进结节消退,且创伤小,术后并发症发生率低,可在临床推广应用。
Objective To analyze curative effect of microwave ablation(MWA)on benign thyroid nodules and its influences on levels of serum triiodothyronine(T3),thyroxine(T4)and thyroid stimulating hormone(TSH).Methods 102 patients with benign thyroid nodules admitted to hospitals from June 2017 to May 2019 were enrolled.They were randomly divided into observation group(n=51,MWA)and control group(n=51,thyroid nodes resection).The surgical situation was compared between the two groups,and nodule regression in the observation group within 6 months after surgery was recorded.Thyroid function(T3,T4,TSH)before and after treatment,and incidence of complications were compared between the two groups.Results The operation time and postoperative hospital stay of observation group were shorter than those of control group(P<0.05).The volume of thyroid nodules in observation group decreased after operation(P<0.05).The volume reduction rates in observation group at 3 months and 6 months after operation were 30.45%and 79.70%,respectively.After treatment,serum T3 and T4 in both group decreased,while TSH levels increased(P<0.05).Besides,serum T3 and T4 levels in observation group after treatment were lower than those in control group,while the TSH level was obviously higher than that in control group(P<0.05).The incidence of complications in observation group was lower than that in control group(P<0.05).Conclusion MWA is effective in the treatment of benign thyroid nodules.It can effectively preserve thyroid function and promote nodular regression,with little trauma and low incidence of postoperative complications.
作者
黄大翠
杨向贵
刘雪婷
袁惠芸
夏林玉
HUANG Dacui;YANG Xianggui;LIU Xueting;YUAN Huiyun;XIA Linyu(Department of Surgery,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China;Department of Clinical Laboratory,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China;Department of Gastrointestinal Surgery,West China Hospital,Sichuan University,Chengdu 610041,China;Department of Orthopaedics,Western Theater Hospital,Chengdu 610083,China;Department of Breast Surgery,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)
出处
《西部医学》
2020年第8期1180-1183,1188,共5页
Medical Journal of West China
基金
国家自然科学基金(81802072)。
