摘要
目的:探讨肝硬化患者血清甲状腺素、可溶性细胞间黏附分子-1(sICAM-1)及可溶性黏附分子P-选择素(sP-selectin)水平与肝纤维化的相关性。方法:抽取2016年6月至2019年6月郑州市第三人民医院86例肝硬化患者进行研究,参照Child-Pugh分类法将其分为Child A组39例、Child B组27例、Child C组20例,比较三组患者血清甲状腺素[三碘甲状腺原氨酸(T3)、四碘甲状腺原氨酸(T4)]、sICAM-1、sP-selectin以及肝纤维化指标[透明质酸(HA)、层黏连蛋白(LN)、III型前胶原(PIIIP)、IV型胶原(CIV)]水平,采用Pearson检验分析血清甲状腺素、sICAM-1、sP-selectin与肝纤维化指标的相关性。结果:三组患者血清T3、T4及sICAM-1、sP-selectin水平比较差异均有统计学意义(P均<0.05),其中Child A组、Child B组血清T3、T4均高于Child C组,且Child A组高于Child B组,Child A组、Child B组血清sICAM-1、sP-selectin水平均低于Child C组,且Child A组低于Child B组(P均<0.05);Child A组、Child B组、Child C组患者血清HA、LN、PIIIP、CIV水平呈现依次升高趋势(P<0.05);Pearson相关性分析结果显示,血清T3、T4水平均与HA、LN、PIIIP、CIV呈负相关关系,血清sICAM-1、sP-selectin水平均与HA、LN、PIIIP、CIV呈正相关关系(P均<0.05)。结论:肝硬化患者血清甲状腺素、sICAM-1、sP-selectin均与肝纤维化指标密切相关。
Objective To investigate the correlation between levels of serum thyroxine,soluble intercellular adhesion molecule-1(sICAM-1)and soluble adhesion molecule P-selectin(sP-selectin)and liver fibrosis in patients with liver cirrhosis.Methods A total of 86 patients with liver cirrhosis in Third People’s Hospital of Zhengzhou from June 2016 to June 2019 were included in the study.According to the Child-Pugh classification,they were divided into Child A group(39 cases),Child B group(27 cases)and Child C group(20 cases).The serum thyroxine[triiodothyronine(T3),tetraiodothyronine(T4)],sICAM-1,sP-selectin and liver fibrosis indicators[hyaluronic acid(HA),laminin(LN),type III procollagen(PIIIP),type IV collagen(CIV)]were compared among the three groups.Pearson test was used to analyze the correlation between serum thyroxine,sICAM-1 and sP-selectin and liver fibrosis indicators.Results There were statistically significant differences in the levels of serum T3,T4,sICAM-1 and sP-selectin among the three groups(P<0.05),and the levels of serum T3 and T4 in Child A group and Child B group were higher than those in Child C group,and the levels in Child A group were higher than those in Child B group.The levels of serum sICAM-1 and sP-selectin in Child A group and Child B group were lower than those in Child C group,and the levels in Child A group were lower than those in Child B group(all P<0.05).The levels of serum HA,LN,PIIIP and CIV in Child A group,Child B group and Child C group showed a increasing trend in turn(P<0.05).Pearson correlation analysis showed that the levels of serum T3 and T4 were negatively correlated with HA,LN,PIIIP and CIV,and the levels of serum sICAM-1 and sP-selectin were positively correlated with HA,LN,PIIIP and CIV(all P<0.05).Conclusions Serum thyroxine,sICAM-1 and sP-selectin are closely related to liver fibrosis indicators in patients with liver cirrhosis.
作者
何慧霞
贺德志
王晓娜
He Huixia;He Dezhi;Wang Xiaona(Department of Gastroenterology,Third People’s Hospital of Zhengzhou,Zhengzhou 450000,China;Department of Gastroenterology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《中国实用医刊》
2020年第14期45-48,共4页
Chinese Journal of Practical Medicine
