摘要
目的 研究肝功能异常伴抗可溶性肝抗原/肝胰抗原(SLA/LP)抗体阳性患者临床与实验 室特点。方法 收集肝功能异常患者血清5500例，分别完成相关自身抗体的检测。结果 8例(0．15%) 患者榆测出 SLA/LP 抗体阳性，女性6例，以中老年女性为主，男性2例，年龄分别为27岁和33岁，8例 中6例无甲、乙、丙、丁、戊型等病毒性肝炎现症感染证据，2例分别伴乙、丙型肝炎病毒标志物，无现症 感染证据。8例中7例已发展至肝硬化，除 SLA/LP 抗体阳性外，抗核抗体均为阳性，部分患者伴抗平滑肌 抗体，抗线粒体抗体，抗线粒体抗体亚型-丙酮酸脱氧酶复合物阳性。结论 SLA/LP 抗体在所检测患者 中阳性率较低，以女性患者为主，多数临床与实验室特点符合自身免疫性肝炎特征，女性患者慢性肝病原 因未名者应检测此抗体。
Objective To analyze the clinical and laboratory features of anti-soluble liver antigen/liver-pancreas （SLA/LP） autoantibody positive patients with abnormal liver functions. Methods From September 1999 to June 2004, 5500 serum samples from patients with abnormal liver functions （ALT 〉 40 U/L） were collected. A series of autoantibody examinations was carried out. Clinical manifestations and laboratory findings of 8 patients with anti-SLA/LP autoantibody positive were reviewed. Results Among the 5500 serum samples, 8 cases （6 females and 2 males） with positive anti-SLA/LP autoantibodies were found with complete clinical information. The age of the patients was （27-76） years old. The case histories were from 2 years to 10 years. Of the 8 patients, 6 cases had liver cirrhosis and HBsAgnegative and anti-HCV-negative, 1 case had liver cirrhosis with HBsAg-positive, but HBVDNA negative; 1 case had anti- HCV positive, but HCV RNA negative. The 8 cases were all ANA positive with titers of 1：320. Four cases were AMA positive and 2 of these 4 cases were M2 positive. The most frequent symptoms were fatigue, anorexia, nausea, jaundice, abdominal distention and edema of lower limbs. All patients had high hypergammaglobulinemia. Conclusion Anti-SLA/ LP autoantibody was at a low detection rate in the study with females in preponderance, Clinical and laboratory characteristics of the 8 cases were consistent with those of the autoimmune hepatitis （AIH）. Testing for anti-SLA autoantibodies helps in the diagnosis of AIH in many patients who may otherwise be misdiagnosed.
出处
《中华肝脏病杂志》
CAS
CSCD
北大核心
2005年第12期927-929,共3页
Chinese Journal of Hepatology
基金
北京市科委技划项目(HO20920020190)
