摘要
良好的睡眠对人体健康至关重要,而遗传因素、环境刺激、疾病和药物等都会破坏睡眠-觉醒结构,导致睡眠障碍。近年来,随着社会的发展,生活压力逐渐加大,失眠的发病率呈上升并呈年轻化趋势。本文主要从促进睡眠的角度来简述睡眠药物发展的历史及当前研发聚焦的靶点,以助临床更好地了解镇静催眠药物并合理使用。
Good sleep is critical for human health.However,numerous factors will disturb the sleep-wake profile,such as heredity,environmental stimulus,diseases&drugs and so on,ultimately leading to sleep disorder.Too much sleep and lack of sleep are two main clinical manifestations,and the insomnia incidence is rising and shows younger trend with the development of society in recent years.We will briefly introduce the history of sleep-promoting medicine and the current targets for research and discovery,in order to help people know more about hypnotics and use them more rationally.
作者
章彬佳
邱子梁
张杰
ZHANG Binjia;QIU Ziliang;ZHANG Jie(Shanghai Haitian Pharmaceutical Technology Development Co.,Ltd.,Shanghai 200032,China)
出处
《世界睡眠医学杂志》
2020年第7期1169-1173,共5页
World Journal of Sleep Medicine
关键词
睡眠
药物发展
药物研发
Sleep
Drug development
Drug research and discovery
