摘要
目的研究血小板相关参数与炎性指标在不同严重程度急性胰腺炎患者中的诊断效能和相关性。方法回顾性分析四川大学华西医院2019年1月—8月确诊为急性胰腺炎的患者88例,分为轻症急性胰腺炎组(n=58)和重症急性胰腺炎组(n=30),收集患者血小板相关参数以及炎性指标的水平,比较两组间差异,分析其诊断效能及相关性。结果重症急性胰腺炎组患者的血小板计数和血小板压积低于轻症急性胰腺炎组,差异具有统计学意义(Z=–5.502、–3.673,P<0.001),而未成熟血小板比率、血小板分布宽度、平均血小板体积及大血小板比例高于轻症急性胰腺炎组,差异具有统计学意义(Z=–4.217、–2.998、–3.754、–3.816,P<0.05)。血小板相关参数血小板计数、未成熟血小板比率、血小板分布宽度、平均血小板体积、大血小板比例和血小板压积以及炎性指标降钙素原、白细胞介素-6在鉴别急性胰腺炎严重程度时,受试者工作特征曲线下面积均大于0.75,具有较好的诊断效能。相关性分析显示,急性胰腺炎患者的未成熟血小板比率与降钙素原、白细胞介素-6的水平呈正相关(相关系数rs分别为0.457、0.385,P<0.05)。结论急性胰腺炎患者的未成熟血小板比率与病情严重程度相关,且与炎性指标降钙素原、白细胞介素-6的水平呈正相关性。
Objective To find out the diagnostic power and correlation between platelet-related parameters and inflammatory indicators in acute pancreatitis patients with different severity.Methods A total of 88 patients with acute pancreatitis diagnosed in West China Hospital of Sichuan University from January 2019 to August 2019 were enrolled in the retrospective study,including 58 mild acute pancreatitis patients and 30 severe acute pancreatitis patients.The patients’platelet-related parameters and inflammatory indicators were collected.The platelet parameters and inflammatory indicators in different severity acute pancreatitis groups were compared and the diagnostic power and correlation were analyzed.Results The platelet count and plateletcrit of the severe group were lower than those of the mild group,the difference was statistically significant(Z=–5.502,–3.673;P<0.001).The immature platelet fraction,platelet distribution width,mean platelet volume and platelet-large cell ratio levels of the severe group were higher than those of the mild group(Z=–4.217,–2.998,–3.754,–3.816;P<0.05).Platelet-related parameters platelet count,immature platelet fraction,platelet distribution width,mean platelet volume,platelet-large cell ratio,plateletcrit and inflammatory indicators procalcitonin,interleukin-6 showed good diagnostic power with areas under under receiver operating characteristic curves greater than 0.75 in differentiating the severity of acute pancreatitis.Correlation analysis showed that immature platelet fraction was positively correlated with procalcitonin and interleukin-6 levels in patients with acute pancreatitis(rs=0.457,0.385;P<0.05).Conclusions Immature platelet fraction is correlated with the severity of acute pancreatitis,and positively correlated with the levels of inflammatory indicators procalcitonin and interleukin-6.
作者
付阳
张琦
李梦雨
苗强
魏彬
江虹
牛倩
FU Yang;ZHANG Qi;LI Mengyu;MIAO Qiang;WEI Bin;JIANG Hong;NIU Qian(Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,P.R.China)
出处
《华西医学》
CAS
2020年第8期943-947,共5页
West China Medical Journal
基金
四川省科学技术厅科技计划项目(2020YFS0126)。
关键词
急性胰腺炎
血小板相关参数
未成熟血小板比率
炎性指标
Acute pancreatitis
Platelet-related parameters
Immature platelet fraction
Inflammatory indicators
