摘要
目的检测健康成年人和败血症患者外周血的未成熟血小板分数(IPF)和其他血小板参数,建立IPF参考区间,探讨IPF与其他血小板参数的相关性及在败血症患者中的临床应用价值。方法筛选379名健康体检者和80例败血症患者、50例发热患者、45例肺炎患者的血常规标本,利用全自动血细胞分析仪PLT-F通道检测外周血IPF,比较健康成人中不同性别和不同年龄区间以及疾病组(败血症组、发热组和肺炎组)与健康成人的IPF值的差异,并分析IPF与血小板(PLT)、血小板分布宽度(PDW)、大血小板比例(P-LCR)、平均血小板容积(MPV)和平均血小板比容(PCT)的相关性。结果健康成人IPF值数据呈非正态分布,不同性别、不同年龄区间IPF值差异均无统计学意义(P>0.05),IPF%的参考区间(P2.5~P97.5):0.70%~6.50%;败血症患者IPF%百分位数(P2.5~P97.5)范围为1.10%~11.79%,显著高于健康成人、发热患者(0.70%~6.96%)和肺炎患者(1.00%~6.79%),差异均有统计学意义(P<0.01);4组的IPF值均与PDW、P-LCR、MPV呈显著正相关,与PLT、PCT呈负相关。结论 IPF具有作为临床预测和早期诊断败血症的新的生物指标的潜力,IPF与血小板其他参数具有显著相关性,联合应用能指导临床综合判断血小板生长情况,评估疾病状态。
Objective We detected immature platelet fraction(IPF) and other platelet parameters of peripheral blood of healthy adults and septicemia patients to establish reference interval of IPF;the correlation between IPF and other platelet parameters was investigated and their clinical application value in sepsis was evaluated.Methods Blood routine specimens of 379 healthy adults,80 septicemia patients,50 patients with fever,and 45 patients with pneumonia were screened using PLT-F channel of automatic blood-cell analyzer.The statistic differences between different sex and different age intervals,as well as between healthy adults and disease groups(septicemia patients,patients with fever,and patients with pneumonia)were compared.The correlation between IPF and counter of platelet(PLT),platelet distribution width(PDW),plateletlarge cell ratio(P-LCR),mean platelet volume(MPV),and thrombocytocrit(PCT) were analyzed.Results The IPF values of healthy adults were abnormally distributed.There was no statistically significant difference in IPF values between different genders and different ages(P>0.05).The reference interval for IPF%(P2.5-P97.5):0.70%-6.50%;IPF%(P2.5-P97.5)in sepsis patients ranged from 1.10% to 11.79%,and was significantly higher than those of healthy adults,fever patients(0.70%-6.96%) and pneumonia patients(1.00%-6.79%)(P<0.01).The IPF values of the 4 groups were significantly positively correlated with PDW,P-LCR,MPV,and negatively correlated with PLT and PCT.Conclusion IPF had the potential to be a new biological indicator for clinical prediction and early diagnosis of sepsis.IPF was significantly correlated with other platelet parameters.The combination of IPF and platelet parameters could guide clinical comprehensive judgment of platelet growth and assess disease status.
作者
童欣欣
杨惠宽
罗淑兰
陈小洁
魏亚明
TONG Xin-xin;YANG Hui-kuan;LUO Shu-lan;CHEN Xiao-jie;WEI Ya-ming(Department of Blood Transfusion,Guangzhou First Peopled Hospital,Guangzhou,Guangdong 510180,China)
出处
《热带医学杂志》
CAS
2020年第6期820-824,828,共6页
Journal of Tropical Medicine
基金
广州市医药卫生一般引导项目(20171A010241)。
