摘要
目的探讨益气活血通脉法治疗老年慢性心功能不全患者的临床研究。方法将2017年4月—2018年6月收治的120例老年慢性心功能患者随机分为对照组和试验组,每组60例。对照组给予基础抗心功能不全治疗,包括吸氧、利尿剂、血管紧张素转换酶抑制剂、β受体阻滞剂、扩血管药物等,试验组在上述基础上加用中药益气活血通脉方口服,每日1剂,水煎煮300 m L,分早晚两次温服。上述治疗均以14 d为1个疗程,连续治疗2个疗程。检测心功能[左室射血分数(LVEF)、左室短轴缩短率(FS)、舒张早期和舒张晚期最大血流速度比值(E/A)],应用经典的6 min步行试验方法记录患者治疗前后6 min步行距离,应用化学发光免疫分析法检测治疗前后血浆BNP水平变化,应用名尼苏达心衰生活调查表评估患者生活质量,比较临床疗效。结果与治疗前比较,两组LVEF、FS、E/A均升高(P<0.01),6 min步行距离升高(P<0.01),血浆BNP水平降低(P<0.01),体力限制、情绪、症状、社会限制评分均降低(P<0.01);与对照组比较,试验组LVEF、FS、E/A均较高(P<0.01),6 min步行距离较高(P<0.01),血浆BNP水平较低(P<0.01),体力限制、情绪、症状、社会限制评分均较低(P<0.01),总有效率较高(P<0.05)。结论益气活血通脉法治疗老年慢性心功能不全效果满意,值得临床推广应用。
Objective To investigate the clinical study of the method of invigorating Qi,activating blood circulation and dredging pulse in the treatment of elderly patients with chronic cardiac insufficiency.Methods Totally 120 elderly patients with chronic heart function admitted from April 2017 to June 2018 were randomly divided into control group and experimental group,60 cases in each group.The control group was given basic anti-cardiac insufficiency treatment,including oxygen inhalation,diuretics,angiotensin-converting enzyme inhibitors,beta-blockers,vasodilators,etc.On the basis of the above,the experimental group was given Yiqi Huoxue Tongmai Recipe orally,one dose a day,decocted 300 m L in water,taking in the morning and evening.All of the above treatments were treated for 14 days as a course of treatment,with two consecutive courses of treatment.The cardiac function[left ventricular ejection fraction(LVEF),left ventricular short axis shortening rate(FS),ratio of maximal blood flow velocity(E/A) in early and late diastolic phase] was measured.Six-minute walking distance before and after treatment was recorded by classical 6-minute walking test.Changes of plasma BNP level before and after treatment were detected by chemiluminescent immunoassay.The quality of life of patients was assessed by Minnesota Heart Failure Life Questionnaire.We compared the clinical efficacy.Results Compared with those before treatment,LVEF,FS and E/A increased in both groups(P<0.01),6-minute walking distance increased(P<0.01),plasma BNP level decreased(P<0.01),physical limitation,mood,symptoms and social limitation scores decreased(P<0.01).Compared with those of the control group,LVEF,FS and E/A were higher(P<0.01),6-minute walking distance was higher(P<0.01),and plasma BNP level was lower(P<0.01).Physical limitation,emotion,symptoms and social limitation scores were lower(P<0.01),and the total effective rate was higher(P<0.05).Conclusion Supplementing Qi,promoting blood circulation and dredging meridians method is effective on treating seni
作者
王国珍
曾胜
江汉奇
钟展轮
邓欣朝
房楷源
吴珊
李伟强
WANG Guozhen;ZENG Sheng;JIANG Hanqi;ZHONG Zhanlun;DENG Xinchao;FANG Kaiyuan;WU Shan;LI Weiqiang(The Fifth Department of Internal Medicine,Meizhou Second Chinese Medicine Hospital,Meizhou 514000,Guangdong,China)
出处
《辽宁中医杂志》
CAS
2020年第6期130-133,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
广东省中医药局面上科研项目(20191338)。
关键词
慢性心功能不全
益气活血通脉法
心功能
BNP
chronic cardiac insufficiency
supplementing Qi
promoting blood circulation and dredging meridians method
cardiac function
BNP
