摘要
目的:观察血液滤过联合血液灌流治疗急性中毒并发急性肾损伤患者的临床效果。方法:选取81例急性中毒并发急性肾损伤患者作为研究对象,采用随机数字表法分为对照组40例和观察组41例,对照组采用血液灌流,观察组在对照组基础上采用血液滤过,比较两组血尿素氮(BUN)、C反应蛋白(CRP)、血肌酐(SCr)和白细胞(WBC)水平;住院时间、昏迷清醒时间、多尿期时间及并发症发生率。结果:治疗后,观察组BUN、CRP、SCr和WBC水平均明显低于对照组,住院时间、昏迷清醒时间和多尿期时间均明显短于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为4.88%,明显低于对照组的25.00%,差异有统计学意义(P<0.05)。结论:血液滤过联合血液灌流治疗急性中毒并发急性肾损伤患者可降低BUN、CRP、SCr和WBC水平以及并发症发生率,缩短住院时间、昏迷清醒时间和多尿期时间,其效果优于单纯血液灌流治疗效果。
Objective:To explore clinical effects of hemofiltration combined with hemoperfusion in treatment of acute poisoning complicated with acute kidney injury.Methods:81 patients with acute poisoning complicated with acute kidney injury were selected as the research objects,and were divided into control group(n=40)and observation group(n=41)by using the random number table method.The control group was treated with hemoperfusion,while the observation group was given hemofiltration on the basis of that of the control group.Then,the levels of blood urea nitrogen(BUN),C-reactive protein(CRP),serum creatinine(SCr)and white blood cell(WBC),the hospitalization time,the recovery time from coma,the polyuria time,and the complication rate were compared between the two groups.Results:After the treatment,the levels of BUN,CRP,SCr and WBC of the observation group were significantly lower than those of the control group;the hospitalization time,the recovery time from com,and the polyuria time were significantly shorter than those of the control group;and the differences were statistically significant(P<0.05).The incidence of complications in the observation group was 4.88%,which was significantly lower than 25.00%in the control group,and the difference was statistically significant(P<0.05).Conclusions:Hemofiltration combined with hemoperfusion can reduce the BUN,CRP,SCr and WBC levels and the incidence of complications in the patients with acute poisoning complicated by acute kidney injury,and shorten the hospitalization time,the recovery time from coma and the polyuria time.Moreover,it is superior to single hemoperfusion.
作者
袁娟
赫英龙
YUAN Juan;HE Yinglong(Department of Nephrology of the Central Hospital of Jiamusi City,Jiamusi 154002 Heilongjiang,China;Department of Emergency of the First Affiliated Hospital of Jiamusi University,Jiamusi 154002 Heilongjiang,China)
出处
《中国民康医学》
2020年第13期1-3,共3页
Medical Journal of Chinese People’s Health
关键词
血液滤过
血液灌流
急性中毒
肾损伤
并发症
Hemofiltration
Hemoperfusion
Acute poisoning
Kidney injury
Complication
