摘要
目的探讨同源框C10(HOXC10)在人脑胶质瘤组织中的表达及其与病人预后的关系。方法选取2013年6月至2018年4月手术切除的胶质瘤组织106例和2018年4月至2019年6月颅脑损伤内减压术中切除的正常脑组织30例,SP法免疫组织化学染色检测HOXC10的表达水平。Cox比例回归风险模型分析总生存期(OS)和无进展生存期(PFS)的影响因素。生存曲线分析HOXC10表达水平与OS和PFS的关系。结果高级别胶质瘤组织HOXC10表达水平明显高于低级别胶质瘤组织(P<0.001),而低级别胶质瘤组织又明显高于正常脑组织(P<0.001)。多因素Cox比例回归风险模型分析显示,WHO分级Ⅲ~Ⅳ级、术后未化疗和HOXC10高表达是胶质瘤病人OS和PFS较短的独立影响因素(P<0.05)。HOXC10高表达组病人中位OS为38个月(四分位间距28~42个月),中位PFS为26个月(四分位间距22~45个月);HOXC10低表达组中位OS为47个月(四分位间距36~54个月),中位PFS为48个月(四分位间距44~53个月)。HOXC10低表达组OS和PFS均明显高于高表达组(P<0.05)。结论人脑胶质瘤组织HOXC10表达水平明显增高,与不良生存预后和肿瘤进展有关。
Objective To explore the expression level of homeobox C10(HOXC10)in human glioma tissues and its relationship with the prognosis of patient with glioma.Methods The expression levels of HOXC10 were detected by SP immunological staining in glioma tissues which were obtained from 106 patients with glioma underwent surgery from June 2013 to April 2018 and in normal brain tissues which were obtained from 30 patients with traumatic brain injury underwent decompression from April 2018 to June 2019.Cox proportional regression risk model was used to analyze the risk factors for overall survival(OS)and progression-free survival(PFS).The survival curve was used to analyzes the relationship between the expression level of HOXC10 and OS and PFS.Results The expression level of HOXC10 of high-grade glioma tissues was significantly higher than that of low-grade glioma tissues(P<0.001),which was significantly higher than that of normal brain tissue(P<0.001).Multivariate Cox proportional regression risk model analysis showed that WHO gradeⅢ~Ⅳ,no postoperative chemotherapy,and high expression of HOXC10 were independent risk factors of shorter OS and PFS of glioma patients(P<0.05).The median OS of patients with high expression of HOXC10 was 38 months(interquartile,28~42 months),and the median PFS was 26 months(interquartile,22~45 months).The median OS of patients with low expession of HOXC10 was 47 months(interquartile,36 to 54 months),and the median PFS was 48 months(interquartile,44~53 months).The OS and PFS of patients with low expression of HOXC10 were significantly higher than those of patients with high expression of HOXC10(P<0.05).Conclusion The expression level of HOXC10 in human glioma tissues is significantly increased,which is related to poor survival prognosis and tumor progression of patients with glioma.
作者
崔敬
佟建洲
CUI Jing;TONG Jian-zhou(Department of Neurosurgery,West Hospital,Baoding First Central Hospital,Hebei 071000,China)
出处
《中国临床神经外科杂志》
2020年第8期513-516,共4页
Chinese Journal of Clinical Neurosurgery
