摘要
前列腺癌是男性生殖系统最常见的恶性肿瘤,严重威胁男性身体健康。已有研究表明,锌离子的存在会抑制前列腺癌细胞的生长。此外,对癌症的光热治疗因其精确度好,治疗效率高,受到越来越广泛的关注。在本研究中,制备了锌离子负载的黑磷纳米片(BP-Zn),评价了该系统对人前列腺癌细胞(PC-3)的光热治疗效果,还评价了锌离子对PC-3细胞的抑制效果,证明了锌离子对于PC-3的毒性具有浓度和时间依赖性。此外,从体外治疗中可以看出,锌离子辅助下黑磷光热治疗效果优于单独黑磷的光热治疗效果。本研究进一步探讨了BP-Zn在体内的治疗效果,结果再次证实,锌离子和BP的联合光热治疗具有优异的抗肿瘤效果。所有动物实验均经过清华大学深圳国际研究生院动物伦理委员会批准。
Prostate cancer is the most common malignant tumor of male reproductive system,which seriously threatens men’s health.It has been shown that the existence of zinc ions can inhibit the growth of prostate cancer cells.In addition,photothermal treatment of cancer is attracting more and more attention due to its high accuracy and efficiency.In this study,zinc ions loaded black phosphorus nanosheets(BP-Zn)were prepared,and the photothermal therapy efficiency of the system on human prostate cancer cells(PC-3)was evaluated.The inhibition effect of zinc ions on PC-3 cells was studied.It was demonstrated that the toxicity of zinc ions on PC-3 cells was concentration-and time-dependent.Moreover,it can be seen from in vitro photothermal therapy that the treatment effect of black phosphorus assisted by zinc ions is superior to that of black phosphorus alone.This study further studied the in vivo therapeutic effect of BP-Zn.The results once again confirmed that the combinational photothermal treatment of zinc ions and BP had excellent anti-tumor effect.The animal procedures were approved by the Animal Ethics Committee of Tsinghua Shenzhen International Graduate School.
作者
苏丽娜
张锦勰
邓颖慧
周韵
盛常富
梅林
SU Li-na;ZHANG Jin-xie;DENG Ying-hui;ZHOU Yun;SHENG Chang-fu;MEI Lin(Department of Pharmacy,Qujing Medical College,Qujing 655000,China;Tsinghua Shenzhen International Graduate School,Shenzhen 518055,China;School of Pharmaceutical Sciences(Shenzhen),Sun Yat-Sen University,Shenzhen 518107,China)
出处
《药学学报》
CAS
CSCD
北大核心
2020年第7期1666-1671,共6页
Acta Pharmaceutica Sinica
基金
国家优秀青年科学基金资助项目(31922042)
云南省教育厅科学研究基金项目(2018JS629)。
关键词
光热治疗
黑磷
锌离子
前列腺癌
联合治疗
photothermal therapy
black phosphorus
zinc ion
prostate cancer
combination therapy
