摘要
近年来多模式联合抗肿瘤成为临床肿瘤治疗的有效策略。光热治疗以其微创、可控、高效、特异性强等特点,可有效弥补传统药物治疗造成的毒副作用、肿瘤耐药等不足。研究表明将光热治疗与化疗联合,表现出较好的协同抗肿瘤效果。然而,化疗药物和光热试剂可能具有不同的体内药动学行为,难以保证两者在肿瘤部位的有效传递,且存在游离形式在体内易被代谢降解等问题。如何将两种治疗模式的药物/光热试剂专属、高效、同步递送到肿瘤组织,以达到最佳联合抗肿瘤效果,是两者联合抗肿瘤应用亟需解决的重要问题。纳米递药技术的发展为肿瘤治疗的应用提供了新思路,本文结合该领域的最新研究进展,从光热治疗联合化疗抗肿瘤机制、纳米共载递药优势、常用的纳米材料类型特点及载药原理方面进行综述,旨在为肿瘤多模式联合治疗的进一步发展提供参考。
In recent years,multi-modal combined anti-tumor has become an effective strategy for clinical tumor treatment.Photothermal therapy with its characteristics of minimally invasive,controllable,high efficiency,and strong specificity,can effectively make up for the toxic side effects and tumor resistance caused by traditional drug treatment.The research shows that the combination of photothermal therapy and chemotherapy has better synergistic antitumor effect.However,chemotherapeutic drugs and photothermal agents may have different pharmacokinetic behaviors in vivo,so it is difficult to ensure their effective transmission in tumor site,and the free form is easy to be metabolized and degraded in vivo.How to deliver the two therapeutic modes of drugs/photothermal reagents to tumor tissues in a specific,efficient and synchronous manner to achieve the best combined antitumor effect is an important problem to be solved in the combined antitumor application.The development of nano-drug delivery technology provides a new idea for the application of tumor treatment.In this paper,combined with the latest research progress in this field,the anti-tumor mechanism of photothermal therapy combined with chemotherapy,the advantages of nano drug delivery,the types and characteristics of commonly used nano materials and the principle of drug delivery are reviewed in order to provide a reference for the further development of multi-mode combined treatment of tumor.
作者
胥海婷
吴亿晗
石金凤
李佳鑫
章津铭
傅超美
XU Hai-ting;WU Yi-han;SHI Jin-feng;LI Jia-xin;ZHANG Jin-ming;FU Chao-mei(School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)
出处
《药学学报》
CAS
CSCD
北大核心
2020年第8期1774-1783,共10页
Acta Pharmaceutica Sinica
基金
国家自然科学基金青年项目(81703718)
国家自然科学基金面上项目(81973662)。
关键词
光热治疗
纳米载体
化疗药物
共递送
肿瘤治疗
photothermal therapy
nanocarrier
chemotherapy drug
co-delivery
tumor therapy
