摘要
目的:探讨轻型地中海贫血(简称地贫)对双胎妊娠母儿结局的影响。方法:选取广西医科大学第一附属医院产科2013年1月至2019年12月收治的42例双胎轻型地贫产妇作为观察组,另选取197例双胎非地贫产妇作为对照组,回顾性分析两组临床资料,比较两组妊娠并发症、妊娠结局和孕期用药情况。结果:观察组孕早期、分娩前血红蛋白(HGB)水平分别为(108.79±9.44)g/L、(101.20±22.33)g/L,均明显低于对照组的(119.88±11.47)g/L、(110.68±15.75)g/L(均P<0.05);观察组孕早期血清铁蛋白(SF)水平、孕期SF下降比率分别为(95.94±69.74)μg/L、0.750 5±0.358 2,显著高于对照组的(70.31±65.72)μg/L、0.593 3±0.615 1(均P<0.05);观察组分娩前缺铁性贫血发生率明显高于对照组(P<0.05);两组产科并发症发生率的比较均无统计学差异(均P>0.05)。观察组产后出血量为(300.0±200.0)mL,明显低于对照组的(400.0±200.0)mL(P<0.05);观察组孕期对铁剂和中成补血药的使用率显著高于对照组(均P<0.05)。结论:轻型地中海贫血使双胎妊娠产妇更易出现妊娠期贫血。
Objective: To explore the effect of thalassemia minor(thalassemia for short) on the outcome of mother and child in twin pregnancy. Methods: 42 twin pregnant women with thalassemia minor who were admitted to the Obstetrics Department of the First Affiliated Hospital of Guangxi Medical University from January 2013 to December 2019 were selected as the observation group, and 197 twin pregnant women without thalassemia were selected as the control group. The clinical data of the two groups were retrospectively analyzed, compared in terms of pregnancy complications, pregnancy outcome, and medication during pregnancy between two groups.Results: The levels of hemoglobin(HGB) during the first trimester(108.79 ± 9.44 g/L)and before delivery(101.20±22.33 g/L)in the observation group were significantly lower than those in the control group(first trimester:119.88 ± 11.47 g/L;before delivery:110.68 ± 15.75 g/L)(both P<0.05).The serum ferritin(SF) level in early pregnancy(95.94 ± 69.74 μg/L)and the rate of SF(0.7505 ± 0.3582) decline during pregnancy in the observation groupwere significantly higher than those in the control group(early pregnancy:70.31 ± 65.72μg/L;rate of SF:0.5933±0.6151)(both P<0.05).The incidence of iron-deficiency anemia before delivery in the observation group was significantly higher than that in the control group(P<0.05).There was no significant difference in the incidence of obstetric complications in the two groups(all P>0.05). The amount of postpartum hemorrhage in the observation group was(300.0±200.0) mL, which was significantly higher than that in the control group(400.0±200.0) mL(P<0.05).The use rate of iron supplement and blood-enriching Chinese patent medicinesin the observation group during pregnancy weresignificantly higher than thosein the control group(P<0.05). Conclusion:Twin pregnant women with thalassemia minor are more likely to have anemia during pregnancy.
作者
罗莉珩
韦莉霞
黄玲玲
Luo Liheng;Wei Lixia;Huang Lingling(Guangxi Medical University Kaiyuan Langdong Hospital,Nanning 530021,China;The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)
出处
《广西医科大学学报》
CAS
2020年第7期1261-1264,共4页
Journal of Guangxi Medical University
基金
国家自然科学基金资助项目(No.81760272)
广西壮族自治区卫生厅自筹经费科研课题(No.Z20170560)。
关键词
地贫
妊娠并发症
妊娠结局
thalassemia
pregnancy complications
pregnancy outcome
