摘要
目的:评估老年高血压患者颈动脉内膜厚度及斑块的发生情况并探讨颈动脉粥样硬化(CAS)的相关因素。方法:采用整群随机抽样法,抽取任丘市城乡100个村和20个社区。入选60岁以上高血压患者2251例,对所有入选者进行颈动脉超声检查。结果:颈动脉正常229例(10.2%),颈动脉内膜中层(IMT)增厚644例(28.6%),颈动脉斑块形成1227例(54.5%),颈动脉狭窄151例(6.7%)。与颈动脉正常组比较,IMT增厚、斑块形成和颈动脉狭窄的男性比例升高,年龄更大,糖尿病、脂代谢紊乱、吸烟、被动吸烟、过量饮酒、缺乏体力活动、抗血小板药物使用的比例逐渐升高,SBP、FPG、TC、LDL-C、HDL-C、尿酸水平逐渐升高,差异有统计学意义(P<0.05)。单因素Logistic分析显示,男性、年龄、糖尿病、脂代谢紊乱、吸烟、被动吸烟、过量饮酒、缺乏体力活动、抗血小板药物使用、SBP、DBP、FPG、TC、LDL-C、尿酸是IMT增厚+CAS的相关因素;男性、年龄、吸烟、被动吸烟、过量饮酒、缺乏体力活动、抗血小板药物使用、SBP、FPG、TC、LDL-C、尿酸是CAS的相关因素;男性、年龄、心房颤动、吸烟、被动吸烟、抗血小板药物使用、SBP、FPG、LDL-C、HDL-C、尿酸是颈动脉狭窄的相关因素。(P<0.05)。男性、年龄、吸烟、缺乏体力活动、抗血小板药物使用、SBP、FPG、LDL-C是CAS的相关因素(P<0.05);男性、年龄、抗血小板药物使用、SBP、LDL-C是颈动脉狭窄的相关因素(P<0.05)。结论:老年高血压患者控制血压、血糖、血脂、血尿酸、减轻体质量、增加运动、戒烟、减少被动吸烟可降低CAS发生率。
Objective:To evaluate the occurrence of carotid intima thickness and plaque in elderly hy-pertensive patients and to explore the related factors of carotid atherosclerosis(CAS).Methods:100 villages and 20 communities in Renqiu city were selected by cluster random sampling.2251 hypertensive patients over 60 years old were selected and carotid artery ultrasound examination was performed on all selected patients.Re.sults:229 cases(10.2%)had normal carotid artery,644 cases(28.6%)had carotid intima-media thickness(IMT),1227 cases(54.5%)had carotid plaque formation and 151 cases(6.7%)had carotid stenosis.Com-pared with normal carotid artery group,the proportion of men with IMT thickening,plaque formation and carotid artery stenosis increased,and the proportion of older men with diabetes,lipid metabolism disorder,smoking,passive smoking,excessive drinking,lack of physical activity and antiplatelet drug use gradually increased.SBP,FPG,TC,LDL-C,HDL-C and uric acid levels gradually increased,with statistically significant difference(P<0.05).Univariate logistic analysis showed that male,age,diabetes,lipid metabolism disorder,smoking,passive smoking,excessive drinking,lack of physical activity,antiplatelet drug use,SBP,DBP,FPG,TC,LDL-C,uric acid were related factors for IMT thickening+CAS.Male,age,smoking,passive smoking,excessive drinking,lack of physical activity,antiplatelet drug use,SBP,FPG,TC,LDL-C,uric acid are related factors for CAS.Male,age,atrial fibrillation,smoking,passive smoking,antiplatelet drug use,SBP,FPG,LDL-C,HDL-C,uric acid are related factors for carotid artery stenosis(P<0.05).Male,age,smoking,lack of physical activity,antiplatelet drug use,SBP,FPG,LDL-C are independent related factors for CAS(P<0.05).Male,age,antiplatelet drug use,SBP and LDL-C are independent related factors for carotid artery stenosis(P<0.05).Conclusions:Elderly patients with hypertension control blood pressure、blood sugar、blood lipids、hemic uric acid、weight loss、increase exercise、quit smoking、reduce the incidence of CA
作者
刘东亮
高素颖
颜应琳
冀瑞俊
于凯
范东娜
王拥军
GAO Suying;YAN Yinglin;JI Ruijun;YU Kai;FAN Dongna;WANG Yongjun(Department of Cardiology,Renqiu Kangjixintu Hospital,Renqiu 062550,China)
出处
《心肺血管病杂志》
2020年第8期936-941,共6页
Journal of Cardiovascular and Pulmonary Diseases
关键词
颈动脉粥样硬化
患病率
相关因素
高血压
Carotid atherosclerosis
Prevalence rate
Related factors
Hypertension
