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原发性高血压患者血清低密度脂蛋白胆固醇及脂蛋白a与血压变异性的相关性 被引量:5

Relationship between low density lipoprotein cholesterol、lipoprotein(a)and blood pressure variability in patients with essential hypertension
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摘要 目的:分析原发性高血压患者血清LDL-C、脂蛋白a[Lp(a)]水平与血压变异性(BPV)的关系。方法:选择2018年01月至2021年10月,在贵州医科大学附属医院高血压科诊疗的原发性高血压患者272例,收集一般临床资料、生化指标以及24h动态血压相关指标。根据LDL-C、Lp(a)诊断切点将研究对象分为四组,A组:LDL-C、Lp(a)均正常;B组:仅Lp(a)升高;C组:仅LDL-C升高;D组:LDL-C、Lp(a)均升高。对比组间24h动态血压监测结果,分析LDL-C、Lp(a)水平与BPV的相关性。结果:24hSBPCV、24hDBPCV、dSBPCV、dDBPCV、nSBPCV等5个指标在A组最低,在D组最高,B、C组介于两组之间。血清Lp(a)、LDL-C-Lp(a)与24hSBPCV、24hDBPCV、dSBPCV、dDBPCV、nSBPCV、nDBPCV呈正相关,LDL-C与24hSBPCV、dSBPCV、nSBPCV呈正相关。结论:原发性高血压患者血清Lp(a)升高和LDL-C、Lp(a)水平同时升高与BPV增大密切相关。 Objective:To analyze the relationship between serum LDL-C,lipoprotein(a)[Lp(A)]levels and blood pressure variability(BPV)in essential hypertension patients.Methods:A total of 272 patients with essential hypertension treated in the Department of Hypertension,the Affiliated Hospital of Guizhou Medical University from January 2018 to October 2021 were selected.General clinical data,blood biochemical indexes and 24h ambulate blood pressure related indexes were collected.According to the diagnostic cut-off points of LDL-C and Lp(a),the subjects were divided into four groups.Group A:LDL-C and Lp(a)were normal;Group B:only Lp(a)increased;Group C:only LDL-C increased;LDL-C and Lp(a)increased in group D.The 24h ambulate blood pressure monitoring results of the four groups were compared,and the correlation between LDL-C,Lp(a)levels and BPV was analyzed.Results:The indexes of 24hSBPCV,24hDBPCV,dSBPCV,dDBPCV and nSBPCV were the lowest in group A and the highest in group D,and the five indexes in group B and C were between the two groups.Serum Lp(a)and LDL-C-Lp(a)were positively correlated with 24hSBPCV,24hDBPCV,dSBPCV,dDBPCV,nSBPCV and nDBPCV,while LDL-C was positively correlated with 24hSBPCV,dSBPCV and nSBPCV.Conclusions:The increase of serum Lp(a)and the simultaneous increase of LDL-C and Lp(a)in essential hypertension patients were closely related to the increase of BPV.
作者 曾婉琪 罗艳 刘丹 余振球 ZENG Wanqi;LUO Yan;LIU Dan;YU Zhenqiu(Department of Hypertension,the Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)
出处 《心肺血管病杂志》 CAS 2022年第7期768-772,共5页 Journal of Cardiovascular and Pulmonary Diseases
关键词 高血压 低密度脂蛋白胆固醇 脂蛋白(a) 血压变异性 Hypertension Low-density lipoprotein cholesterol Lipoprotein(a) Blood pressure variability
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