摘要
变应性鼻炎(allergic rhinitis,AR)是以鼻痒、喷嚏、流清涕、鼻塞等症状为主要特征的一种常见的鼻黏膜慢性炎症性疾病,虽然现有药物能够较好的控制过敏反应,但其复发率高、治愈率低的临床特点,给AR的治疗带来了很大挑战。高迁移率族蛋白B1(high mobility group box-1,HMGB1)是广泛存在于真核动物细胞核中的一类高度保守的非组蛋白,近来研究表明高迁移率族蛋白B1可能通过调节免疫细胞分化、细胞自噬以及上皮细胞损伤等几方面参与气道变应性炎症反应,从而参与了AR的发生、发展过程。本文对HMGB1在AR中的研究进展及作用机制进行阐述,以揭示HMGB1在AR发生过程中的可能意义,为临床治疗和预防AR提供新的参考。
Allergic rhinitis(AR)is one kind of common chronic inflammatory diseases of nasal mucosa,which characterized by symptoms such as nasal itching,sneezing,runny nose,and nasal obstruction.Although symptoms of allergic rhinitis can be controlled very well by recent therapeutic medications,but the clinical characteristics of high morbidity and low cure rate are still big challenges for treatment.Based on results of recent research,it was demonstrated that high mobility group box-1(HMGB1)may play an important role in airway inflammatory response by regulating T cell differentiation,autophagy,and epithelial cell injury,which may be involved in the occurrence and development of AR.The progress on research of the role and its mechanism of HMGB1 in AR were reviewed in this article,for providing the basis for the treatment and prevention of AR.
作者
林小燕
李静
李勇
杨烨
LIN Xiao-yan;LI Jing;LI Yong;YANG Ye(Department of Otolaryngology,The Affiliated Hangzhou Hospital of Nanjing Medical University,Hangzhou 310053,Zhejiang,China;Department of Otolaryngology,fourth school of medical,Zhejiang Traditional Chinese Medical University,Hangzhou 310053,Zhejiang,China)
出处
《中华临床免疫和变态反应杂志》
2020年第3期255-260,共6页
Chinese Journal of Allergy & Clinical Immunology
基金
浙江省医药卫生项目(2016KYB227)
杭州市医药卫生项目(2017A10)
浙江省医药卫生青年人才项目(2019RC066)。
关键词
变应性鼻炎
高迁移率族蛋白
机制
自噬
allergic rhinitis
high mobility group box-1
pathogenesis
autophagy
