摘要
目的探讨Ki-67在肺非典型腺瘤样增生、原位腺癌、微浸润性腺癌及浸润性腺癌中的表达差异。方法选取2010年1月~2019年1月广东医科大学附属医院、农垦中心医院确诊的93例癌前病变/肺腺癌患者进行研究,根据其病理类型不同分为非典型腺瘤样增生组(n=18)、原位腺癌组(n=25)、微浸润性腺癌组(n=22)、浸润性腺癌组(n=28),各组均取适量病变组织并应用免疫组织化学法进行Ki-67表达水平检测,并比较其与临床病理特征的相关性。结果Ki-67在肺非典型腺瘤样增生、原位腺癌、微浸润性腺癌及浸润性腺癌中的表达水平逐渐升高,差异有统计学意义(P<0.05),且Ki-67表达水平在不同组织学分级之间的差异有统计学意义(P<0.05),经Spearman相关性分析发现Ki-67表达与淋巴结转移与否、侵袭转移程度均无相关性(P>0.05),但与组织学分级呈显著的负相关(P<0.05)。结论Ki-67高表达为肺腺癌发生的主要分子事件,可参与肿瘤发展,但具体机制仍有待进行大样本、多中心、多因素分析。
Objective Toinvestigate the differential expression of Ki-67 in atypical adenoma hyperplasi(AAH),adenocarcinoma in situ(ACIS),minimally invasive adenocarcinoma(MIA)and invasive adenocarcinoma(IAC)of lungs.Methods From January 2010 to January 2019,93 patients with precancerous lesions/lung adenocarcinoma diagnosed in the Affiliated Hospital of Guangdong Medical University and Central Hospital of Guangdong Nongken were selected for research.According to their pathological types,they were divided into the AAH group(n=18),the ACIS group(n=25),the MIA group(n=22)and the IAC group(n=28).The appropriate amount of pathological tissues and applied immunohistochemistry were taken in all groups to detect theKi-67 expression level,and their correlation with clinical-pathological features were compared.Results The expression level of Ki-67 in AAH,ACIS,MIA and IAC of lungs gradually increased with statistically significant differences(P<0.05),and the differences of the Ki-67 expression level in different histological grades were statistically significant(P<0.05).Spearman correlation analysis showed that Ki-67 expression had no correlation with lymph node metastasis or not,invasion and metastasis degree(P>0.05),but had significant negative correlations with histological grades(P<0.05).Conclusion Ki-67 overexpression is a major molecular event in lung adenocarcinoma and participates in tumor development,but the specific mechanism still needs to be analyzed by large sample,multicenter and multifactorial analysis.
作者
胡文铧
吴爱兵
李媛媛
谢健龙
王永存
HU Wenhua;WU Aibing;LI Yuanyuan;XIE Jianlong;WANG Yongcun(Pathology Department,Affiliated Hospital of Guangdong Medical University,Guangdong,Zhanjiang 524000,China;Cancer Treatment Center,Affiliated Hospital of Guangdong Medical University,Guangdong,Zhanjiang 524000,China;Ward V of Oncology Department,Central Hospital of Guangdong Nongken,Guangdong,Zhanjiang 524002,China;Department of Cardiothoracic Surgery,Affiliated Hospital of Guangdong Medical University,Guangdong,Zhanjiang 524000,China)
出处
《中国医药科学》
2020年第13期188-190,202,共4页
China Medicine And Pharmacy
基金
广东省科技计划项目(2016A020215228)。
关键词
肺非典型腺瘤样增生
原位腺癌
微浸润性腺癌
浸润性腺癌
KI-67表达
Atypical adenoma hyperplasi of lungs
Adenocarcinoma in situ
Minimally invasive adenocarcinoma
Invasive adenocarcinoma
Ki-67 expression
