摘要
目的探讨肺腺癌多层螺旋CT(MSCT)征象与表皮生长因子受体(EGFR)突变、Ki-67表达水平的相关性。方法收集2017年1月至2017年12月于我院就诊且行MSCT检查128例肺腺癌患者的临床及影像学资料,记录所有患者EGFR突变、Ki-67表达水平及MSCT征象情况,并比较不同患者间MSCT征象情况。结果 128例肺腺癌患者MSCT征象中有胸膜凹陷征52例,瘤肺边界不清晰58例,毛刺佂56例,分叶佂68例,空泡征60例,胸腔积液55例,实性结节型肺腺癌80例和亚实性肺腺癌48例。有EGFR突变阳性60例和EGFR突变阴性68例,Ki-67高表达52例和低表达76例。EGFR突变的阳性率与瘤肺边界、毛刺佂、分叶佂、空泡征和胸腔积液无明显相关性,但存在胸膜凹陷佂和亚实性结节型肺腺癌患者其EGF突变的阳性率显著高于无胸膜凹陷佂和实性结节型肺腺癌患者(P<0.05);而Ki-67的表达与MSCT征象无明显相关性(P>0.05)。结论 Ki-67表达与肺腺癌MSCT征象无相关,而EGFR突变与MSCT征象中的肿瘤结节类型与胸膜凹陷佂有着密切相关性,故准确分析和辨别肺腺癌患者MSCT征象中肿瘤结节类型与胸膜凹陷佂有利于监测其EGFR突变和预估其预后情况。
Objective To investigate the correlation in the multi-slice spiral CT(MSCT) signs of adenocarcinoma of lung, the mutation of endothelial growth factor receptor(EGFR) and expression level of Ki-67. Methods Clinical and imaging data of 128 patients with adenocarcinoma of lung who underwent MSCT examination from January 2017 to December 2017 were collected. All patients were recorded for EGFR mutation, Ki-67 expression level and MSCT signs. The signs of MSCT in different patients were compared. Results Among the 128 patients with lung adenocarcinoma, there were 52 cases with pleural indentation, 58 cases with unclear border of lung with tumor, 56 cases with burr, 68 cases with lobulated sign, 60 cases with vacuole sign, and 55 cases with pleural effusion. 80 cases with solid nodular lung adenocarcinoma and 48 cases with sub-solid lung adenocarcinoma. There were 60 cases with positive EGFR mutation and 68 cases with negative EGFR mutation, and 52 cases with high expression of Ki-67 and 76 cases with low expression of Ki-67. The positive rate of EGFR mutation was not correlated with border of lung with tumor, burr, lobulated sign, vacuole sign and pleural effusion, but However, the positive rate of EGF mutation in patients with pleural indentation and subsolid nodular lung adenocarcinoma was significantly higher than that in patients without pleural indentation and in patients with solid nodular lung adenocarcinoma(P<0.05). There was no significant correlation between the expression of Ki-67 and the signs of MSCT(P>0.05). Conclusion Ki-67 expression was not associated with MSCT signs of lung adenocarcinoma, but EGFR mutations were closely related to the type of tumor nodules and pleural indentation in MSCT signs. Therefore, accurate analysis and identification for the type of tumor nodule and pleural indentation in the MSCT signs of patients with lung adenocarcinoma is beneficial to monitor the EGFR mutation and predict its prognosis.
作者
陈威
冯维忠
王刚
CHEN Wei;FENG Wei-zhong;WANG Gang(Department of Thoracic Surgery,Langzhong People's Hospital,Langzhong 637400,Sichuan Province,China)
出处
《中国CT和MRI杂志》
2020年第7期45-47,69,共4页
Chinese Journal of CT and MRI
基金
四川省卫计委课题(编号:16ZD025)。
关键词
肺腺癌
多层螺旋CT
表皮生长因子受体
KI-67
征象
相关性
Lung Adenocarcinoma
Multi-slice Spiral CT
Endothelial Growth Factor Receptor
Ki-67
Signs
Correlation
