摘要
目的探讨T1 mapping与鼻咽癌分期及表皮生长因子受体(epidermal growth factor receptor,EGFR)和Ki-67的相关性。材料与方法回顾性分析鼻咽癌初诊患者病例48例,行鼻咽加颈部MRI常规平扫、增强及T1 mapping序列扫描,测量肿瘤区增强前、增强后T1值以及其差值(分别记录为T1_(pre)、T1_(post)、ΔT1),并测量增强前、增强后肿瘤区与同侧C3水平胸锁乳突肌T1差值(分别记录为ΔT1_(preS)、ΔT1_(postS))。将临床分期、T及N分期分为2组,低分期组:临床分期Ⅰ+Ⅱ期19例、T分期T_(1)+T_(2)38例、N分期N_(0)+N_(1)18例;高分期组:临床分期Ⅲ+Ⅳ期29例、T分期T_(3)+T_(4)10例、N分期N_(2)+N_(3)30例。鼻咽癌高、低分期组间T1值采用两独立样本t检验,并绘制受试者工作特征(receiver operating characteristic,ROC)曲线分析诊断效能,T1值与Ki-67表达分数的相关性采用Pearson相关分析,T1值与EGFR的相关性采用Spearman相关分析。结果高分期组T1_(pre)、ΔT1、ΔT1_(preS)均值均高于低分期组,T1_(pre)、ΔT1、ΔT1_(preS)对于临床分期、N分期差异有统计学意义(P<0.05),ΔT1_(preS)对T分期差异没有统计学意义(P=0.197),T1_(post)及ΔT1_(postS)对鼻咽癌分期差异没有统计学意义(P>0.05);T1_(pre)对于临床分期、N分期的AUC最大(分别为0.927、0.913,P均<0.05);T1_(pre)与EGFR、Ki-67指数呈中度正相关(r=0.61、0.54,P<0.05)。结论T1 mapping与鼻咽癌分期及EGFR、Ki-67指数均有较好的相关性,能无创评估肿瘤组织侵袭性和增殖潜能,有利于个体化治疗方案的制订,降低肿瘤复发及转移的风险。
Objective:To explore the correlation between T1 mapping,epidermal growth factor receptor(EGFR)and Ki-67 index and its value in clinical staging of nasopharyngeal carcinoma(NPC).Materials and Methods:Forty-eight newly diagnosed NPC patients were analyzed.All patients underwent nasopharyngeal and neck MRI routine plain scans,dynamic enhanced scans and T1 mapping sequence scans.Pre-enhancement relaxation time(T1_(pre)),post-enhancement relaxation time(T1_(post)),the difference relaxation time of the tumor area before and after enhancement(ΔT1),pre-enhancement relaxation time between tumor area and the sternocleidomastoid muscle area at C3 level(ΔT1_(preS)),post-enhancement relaxation time between tumor area and the muscle area(ΔT1_(postS))were obtained.T,N and clinical stages were divided into two groups:low-stage group:19 cases of clinical stageⅠ+Ⅱ,38 cases of T stage T_(1)+T_(2),18 cases of N stage N_(0)+N_(1);high-stage group:29 cases of clinical stageⅢ+Ⅳ,10 cases of T stage T_(3)+T_(4),30 cases of N stage N_(2)+N_(3).The T1 values between the high and low stage groups of NPC were tested by two independent samples,and the receiver operating characteristic(ROC)curve of the subjects was drawn to analyze the diagnostic efficiency.Pearson analysis was used to analyze the T1 values and Ki-67 index.Spearman correlation analysis was used to analyze the T1 values and EGFR.Results:T1_(pre),ΔT1 andΔT1_(preS) in the high-stage group were higher than those in the low-stage group.T1pre,ΔT1pre andΔT1_(preS) were significantly correlated with clinical and N stage(P<0.05),but there was no significant difference between ΔT1(preS) and T stage(P=0.197).T1post andΔT1postS had no significance difference in the staging of NPC(P>0.05).T1pre had the highest AUC for clinical stage and N stage(0.927,0.913,P<0.05).T1pre was moderately positively correlated with EGFR and Ki-67 index(r=0.61,0.54,P<0.05).Conclusions:T1 mapping has a good correlation with clinical staging of NPC,EGFR and Ki-67 index.It can noninvasively evalua
作者
邓凌达
郭保亮
杜勇兴
胡秋根
DENG Lingda;GUO Baoliang;DU Yongxing;HU Qiugen(Department of Radiology,Shunde Hospital of Southern Medical University,Foshan 528306,China)
出处
《磁共振成像》
CAS
CSCD
北大核心
2022年第3期66-70,共5页
Chinese Journal of Magnetic Resonance Imaging
基金
广东省医学科研基金项目(编号:A2020395)。
关键词
磁共振成像
鼻咽癌
分期
预后
T1
mapping
KI-67
表皮生长因子受体
magnetic resonance imaging
nasopharyngeal carcinoma
staging
medical prognosis
T1 mapping
Ki-67
epidermal growth factor receptor
