摘要
目的探讨白细胞介素-8(IL-8)、白细胞介素-6(IL-6)、超敏C-反应蛋白(hs-CRP)在缺血性脑血管病(ICD)手术前后表达变化及临床价值.方法选取本院ICD患者122例作为观察组,另选取同期健康体检者120例作为对照组.观察组均行血管内介入治疗,比较两组血清IL-8、IL-6、hs-CRP水平,分析观察组术前、术后1、2、3个疗程时血清因子水平变化趋势,随访1年,分生存者、死亡者,比较不同预后患者临床资料及术前、术后1、2、3个疗程时血清因子水平,分析ICD患者1年后死亡的危险因素,Kaplan-Meier曲线进行生存分析.结果观察组血清IL-8、IL-6、hs-CRP水平高于对照组,差异有统计学意义(P<0.05);术后1、2、3个疗程时血清IL-8、IL-6、hs-CRP低于术前,且呈降低趋势(P<0.05);生存者术后1、2、3个疗程时血清IL-8、IL-6、hs-CRP低于术前及死亡者,差异有统计学意义(P<0.05);Logistic回归系数分析显示,血管狭窄、高血压、糖尿病、吸烟、血清IL-8、IL-6、hs-CRP是ICD预后的独立危险因素(P<0.05);术后3个疗程血清IL-8、IL-6、hs-CRP高表达者生存率低于低表达者(P<0.05).结论ICD发病发展受多种因素影响,其中血清IL-8、IL-6、hs-CRP与ICD患者预后关系密切,可作为疾病诊断、预后预测的辅助性指标.
Objective To investigate the expression and clinical value of interleukin-8(IL-8),interleukin-6(IL-6),and hypersensitive C-reactive protein(hs-CRP)before and after operation of ischemic cerebrovascular disease(ICD).Methods 122 cases of ICD patients in Tangshan Likang Hospital were selected as the observation group,and 120 healthy persons in the same period were selected as the control group.The observation group all received intravascular interventional therapy.The levels of serum IL-8,IL-6 and hsCRP between the two groups were measured and compared.The change trend of serum factor levels in the observation group were analyzed before operation and after 1,2,and 3 courses of treatment.Followed up for 1 year,subjects were divided into the survivors and deceased groups,clinical data of patients with different prognosis and serum factor levels were compared during preoperative and postoperative 1,2,and 3 courses of treatment.The risk factors were analyzed for death of ICD patients after 1 year,Kaplan-Meier curve was used for survival analysis.Results The serum levels of IL-8,IL-6 and hs-CRP in the observation group were higher than those in the control group(P<0.05).The serum IL-8,IL-6 and hs-CRP levels in 1,2 and 3 courses after surgery were lower than those before surgery and showed a decreasing trend(P<0.05).The survivors serum IL-8,IL-6 and hs-CRP at 1,2 and 3 courses after surgery were lower than those before surgery and those who died before surgery(P<0.05).Logistic regression coefficient analysis showed that vascular stenosis,hypertension,diabetes,smoking,and serum IL-8,IL-6,hs-CRP levels were independent risk factors for ICD prognosis(P<0.05).The survival rate of those with high expression of serum IL-8,IL-6 and hs-CRP was lower than those with low expression after 3 courses of surgery(P<0.05).Conclusion The development of ICD is affected by many factors,among which the serum IL-8,IL-6,hs-CRP has are closely related to the prognosis of ICD patients,and can be used as an auxiliary indicator for disease diagnos
作者
任英巧
李占增
伍淑玲
陆艳卉
REN Yingqiao;LI Zhanzeng;WU Shuling;LU Yanhui(Neurology Dept,Tangshan Likang Hospital,Tangshan,Hebei,China,063000;Neurology Dept,Tangshan People's Hospital,Tangshan,Hebei,China,063000)
出处
《分子诊断与治疗杂志》
2020年第7期923-927,共5页
Journal of Molecular Diagnostics and Therapy
基金
河北省卫生和计划生育委员会科研基金重点科技研究计划(20191610)。
