摘要
目的探讨老年急性心肌梗死(AMI)患者微小RNA-214(miR-214)、凝集素样氧化型低密度脂蛋白受体1(sLOX-1)和尾加压素Ⅱ表达与疾病严重程度和左心室功能的关系。方法选择2015年6月~2018年6月巴彦淖尔市医院就诊的老年患者180例,其中AMI组110例,冠心病组70例,另选取同期我院健康体检者50例作为对照组。AMI组患者又分为无心力衰竭组53例和心力衰竭组57例。检测各组miR-214、sLOX-1和尾加压素Ⅱ水平以及心功能情况。分析miR-214、sLOX-1和尾加压素Ⅱ水平与心功能的相关性。结果与对照组比较,冠心病组miR-214、sLOX-1水平明显升高,尾加压素Ⅱ、LVEF和心排血量明显降低,差异有统计学意义(P<0.05)。与冠心病组比较,AMI组miR-214、sLOX-1水平明显升高,尾加压素Ⅱ、LVEF和心排血量明显降低,差异有统计学意义(P<0.05)。无心力衰竭组尾加压素Ⅱ水平明显高于心力衰竭组,miR-214和sLOX-1水平明显低于心力衰竭组,差异有统计学意义(P<0.01)。logistic回归分析显示,miR-214、sLOX-1水平升高是AMI后发生心力衰竭的危险因素,而尾加压素Ⅱ水平升高是AMI后发生心力衰竭的保护因素(P<0.01)。Person相关性分析显示,AMI组miR-214与LVEF和心排血量呈负相关(r=-0.602,P=0.000;r=-0.543,P=0.000),sLOX-1与LVEF和心排血量呈负相关(r=-0.466,P=0.000;r=-0.581,P=0.000),尾加压素Ⅱ与LVEF和心排血量呈正相关(r=0.619,P=0.000;r=0.525,P=0.000)。结论miR-214、sLOX-1和尾加压素Ⅱ水平与AMI的发生以及其病情严重程度相关,检测miR-214、sLOX-1和尾加压素Ⅱ水平可对AMI患者进行早期诊断,同时对AMI患者的心力衰竭风险进行早期判断和评估。
Objective To study the relationship of miR-214,lectin-like oxidized LDL receptor 1 and urotensinⅡ(U-Ⅱ)expressions with the severity of acute myocardial infarction(AMI)and left ventricular function in the elderly.Methods One hundred and eighty elderly patients admitted to our hospital from June 2015 to June 2018 were divided into AMI group(n=110)and CHD group(n=70)with 50 persons who underwent physical examination in our hospital served as a control group.The patients in AMI group were further divided into HF-free group(n=53)and HF group(n=57).The serum levels of miR-214,lectin-like oxidized LDL receptor 1 and U-Ⅱwere measured and the cardiac function was assessed in different groups.The relationship of serum miR-214,lectin-like oxidized LDL receptor 1 and U-Ⅱlevels with cardiac function was analyzed.Results The serum miR-214 and lectin-like oxidized LDL receptor 1 levels were significantly higher while the serum U-Ⅱlevel,LVEF and cardiac output were significantly lower in CHD group than in control group(P<0.05).The serum U-Ⅱlevels were significantly higher while those of miR-214 and lectin-like oxidized LDL receptor 1 were significantly lower in HF-free group than in HF group(P<0.01).Logistic regression analysis showed that elevated serum levels of miR-214 and lectin-like oxidized LDL receptor 1 were the risk factors for HF while those of U-Ⅱwere the protective factors for HF in AMI patients(P<0.01).Person correlation analysis displayed that the serum level of miR-214 was negatively related while that of lectin-like oxidized LDL receptor 1 was positively with the LVEF and cardiac output in AMI patients(r=-0.602,r=-0.543,P=0.000;r=-0.466,r=-0.581,P=0.000;r=0.619,r=0.525,P=0.000).Conclusion Serum miR-214,lectin-like oxidized LDL receptor 1 and U-Ⅱlevels are related with the occurrence and severity of AMI.Measurement of serum miR-214,lectin-like oxidized LDL receptor 1 and U-Ⅱlevels can thus contribute to the early detection and assessment of the risk factors for HF in AMI patients.
作者
王永杰
程亚军
Wang Yongjie;Cheng Yajun(Department of General Practice,Bayannur Hospital,Bayannur 015000,Inner Mongolin Automomous Region,China)
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2020年第7期710-713,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
