摘要
目的探讨网膜素-1、内脂素、谷氨酰转肽酶与2型糖尿病患者颈动脉内膜中层厚度(CIMT)的相关性。方法116例2型糖尿病患者根据CIMT分为增厚组(CIMT≥0.9mm)和非增厚组(CIMT<0.9mm),检测两组患者血清网膜素-1、内脂素、谷氨酰转肽酶等相关指标。结果增厚组2型糖尿病患者CIMT、内脂素明显高于非增厚组(P<0.05),网膜素-1明显低于非增厚组(P<0.05);两组谷氨酰转肽酶比较差异无统计学意义(P>0.05)。Spearman相关分析显示,2型糖尿病患者CIMT与网膜素-1呈负相关关系(r=-0.726,P<0.05),与内脂素呈正相关关系(r=0.919,P<0.05)。多因素Logistic回归分析显示,内脂素是2型糖尿病患者CIMT增厚的独立危险因素。结论网膜素-1、内脂素与2型糖尿病患者CIMT具有相关性,可作为早期判断颈动脉粥样硬化的血清学指标。
Objective To investigate the correlations between carotid intima media thickness(CIMT)in patients with type 2 diabetes mellitus and omentin-1,visfatin,glutamyltranspeptidase.Methods The 116 patients with type 2 diabetes mellitus were divided into thickening group(CIMT≥0.9mm)and non-thickening group(CIMT<0.9mm)according to the CIMT.The omentin-1,visfatin and glutamyltranspeptidase in serum of patients in 2 groups were measured.Results The CIMT and visfatin of patients in thickening group were signifi cantly higher than those in non-thickening group(P<0.05),the omentin-1 were signifi cantly lower(P<0.05).There was no signifi cant difference in glutamyltranspeptidase between the two groups(P>0.05).Spearman correlation analysis showed that the CIMT of type 2 diabetic patients negatively correlated with omentin-1(r=-0.726,P<0.05),but positively correlated with visfatin(r=0.919,P<0.05).Multivariate logistic regression analysis showed that visfatin was the independent risk factor for CIMT thickening in type 2 diabetic patients.Conclusion Omentin-1 and visfatinare correlated with CIMTin patients with type 2 diabetesmellitus,which can be used as serological indexs for early diagnosis of carotid atherosclerosis.
作者
王楠
朱红涛
刘晓燕
WANG Nan;ZHU Hong-tao;LIU Xiao-yan(The Affi liated Hospital of Chengde Medical College,Hebei Chengde 06700,China)
出处
《承德医学院学报》
2020年第3期198-201,共4页
Journal of Chengde Medical University
