摘要
目的分析胸腔积液和血清中癌胚抗原(CEA)、腺苷脱氨酶(ADA)、降钙素原(PCT)联合诊断胸腔积液的价值。方法收集2017年1月~2019年5月沈阳市第十人民医院收治的120例结核性胸腔积液患者为对照组;120例恶性胸腔积液患者为观察组。检测血清和胸腔积液中PCT、ADA、CEA水平,分析其鉴别诊断结核性与恶性胸腔积液的效能。绘制ROC曲线观察血清三项指标联合诊断的效能和胸腔积液三项指标联合诊断的效能。结果与对照组相比,观察组血清CEA和胸腔积液PCT、CEA较高,胸腔积液ADA较低,差异均有统计学意义(P<0.05)。单项指标诊断恶性胸腔积液特异度最高为胸腔积液CEA(92.50%),其次为血清CEA(85.83%);灵敏度最高为胸腔积液CEA(85.83%),其次为血清CEA(69.17%)。血清+胸腔积液三项联合将特异度、灵敏度提高至95.83%、90.00%。结论血清+胸腔积液PCT、ADA、CEA能更有效鉴别结核性与恶性胸腔积液。
Objective To analyze the value of CEA,ADA and PCT of pleural effusion and serum in the identification of pleural effusion.Methods 120 patients with tuberculous pleural effusion in Shenyang Tenth people's hospital from January 2017 to May 2019 were collected as control group and 120 patients with malignant pleural effusion as observation group.The levels of PCT,ADA and CEA in serum and pleural effusion were measured,and the efficiency of differentiation of malignant pleural effusion was analyzed.Results Compared with the control group,the serum CEA and pleural effusion CEA,PCT in the observation group were higher,and pleural effusion ADA were lower,and the differences were statistically significant(P<0.05).The highest specificity of single index in the diagnosis of malignant pleural effusion was pleural effusion CEA(92.50%),followed by serum CEA(85.83%),the highest sensitivity was pleural effusion CEA(85.83%),followed by serum CEA(69.17%).The specificity and sensitivity of three combinations of serum plus pleural effusion were increased to 95.83%and 90.00%.Conclusion Serum plus pleural effusion PCT,ADA and CEA are more effective in the treatment of tuberculous and malignant pleural effusion.
作者
陈虹
高鸿美
范立雪
李婷
李微
CHEN Hong;GAO Hongmei;FAN Lixue;LI Ting;LI Wei(Department of Respiratory,Tenth People's Hospital of Shenyang City,Shenyang 110044,China;Department of Laboratory,Tenth People's Hospital of Shenyang City,Shenyang 110044,China)
出处
《中国现代医生》
2020年第15期14-17,共4页
China Modern Doctor
