摘要
目的探讨胸腔积液降钙素原(PCT)、癌胚抗原(CEA)联合检测在恶性胸腔积液中的诊断价值。方法30例恶性、19例结核性胸腔积液患者,采用酶联免疫吸附分析法测定血浆和胸腔积液中的PCT水平,放射免疫法测定CEA的水平。结果恶性胸腔积液的PCT浓度(μg/L)高于结核性胸腔积液(0.373±0.276 vs 0.202±0.121,P<0.05),血浆PCT浓度两者差异无显著性。以PCT浓度0.221μg/L为最佳诊断界值,诊断恶性胸腔积液的敏感性为67%,特异性为74%;以CEA浓度15μg/L为恶性胸腔积液标准,诊断恶性胸腔积液的敏感性为83%,特异性为84%。串联两项检测特异性可提高至95%,并联则可获得97%的敏感性,联合检测优于单项检测。结论PCT测定对于恶性胸腔积液的诊断有一定价值,与CEA联合检测,可以显著提高诊断的敏感性和特异性。但PCT并不比CEA诊断价值高,还需进一步研究。
Objective To observe the diagnostic value of combined detection procalcitonin （PCT） and carcinoembryonic antigen （CEA） in malignant pleural effusion. Methods 30 cases with malignant and 19 cases with tuberclous pleural effusion were enrolled into the study. Enzyme linked immunosorbent assay was used to detect PCT of plasma and pleural effusion, and CEA levels were tested by using radio-immunity. Results The levels of PCT（ μg/ L） in malignant pleural effusion were higher than tuberculous pleural effusion（0. 373 ±0. 276 vs 0. 202 ±0. 121 ,P 〈 0. 05 ）, no significant difference was observed in plasma. Diagnostic sensitivity and specificity value for PCT in malignant effusion were 67% and 74% at the 0. 221 μg/L cut-off value,83% and 84% for CEA at 15 μg/L. When paiallel the two tests, the specificity can elevate to 95%, parallel detection can elevate the sensitivity to 97%. Combined detection better than the single test. Conclusion The detection of PCT had certain value for diagnosing malignant pleural effusion, the combined testing of PCT and CEA can improve the specificity and sensitivity signifi- cantly, but the diagnostic value of PCT not surpass CEA, the use of PCT should be further investigated.
出处
《安徽医科大学学报》
CAS
北大核心
2009年第2期194-196,共3页
Acta Universitatis Medicinalis Anhui
关键词
胸腔积液
恶性/诊断
癌胚抗原
pleural effusion
malignant/diagnosis
carcinoembryonic antigen procalcitonin
