摘要
目的分析丙戊酸盐类药物不良反应的发生特点。方法回顾整理2013年1月~2019年12月某院上报至国家不良反应监测中心的丙戊酸盐类药物不良反应并进行分析。结果230例不良反应中,其中男性124例,女性106例。严重不良反应29例,一般不良反应201例。其中19~30岁年龄段患者占比例最高,达到34.3%。不良反应累及器官或系统主要集中在皮肤及皮下组织(20.2%)、血液淋巴系统(19.9%)、消化系统(17.2%)、肝胆器官(14.9%)和神经系统(14.2%)。不良反应最常发生于用药后2~10 d。结论针对丙戊酸盐类药物不良反应的发生特点,临床用药时应重视其相关影响因素,减少不良反应的发生。
OBJECTIVE To investigate the incidence of adverse reactions(ADR)induced by Valproate and related factors.METHODS The reports of ADR induced by Valproate reported to the National Center for Adverse Drug Monitoring from January 2013 to December 2019 were retrospective reviewed and analyzed.RESULTS Among the 230 ADR reports,124 cases were males and 106 females.29 patients had serious ADR while 201 cases suffer from general ADR.Among them,patients aged 19-30 years old accounted for the highest proportion(34.3%).The side effects observed most frequently included the skin and subcutaneous tissue(20.2%),blood lymph System(19.9%),digestive system(17.2%),hepatobiliary organs(14.9%)and nervous system(14.2%).ADR most occurred 2-10 days after administration.CONCLUSION In term of the occurrence characteristics and related factors associated with ADR induced by Valproate,more attention should be paid on the related factors to reduce the occurrence of adverse reactions.
作者
李璐
王占璋
胡晋卿
卢浩扬
邓书华
张明
朱秀清
倪晓佳
尚德为
温预关
LI Lu;WANG Zhanzhang;HU Jinqing;LU Haoyang;DENG Shuhua;ZHANG Ming;ZHU Xiuqing;NI Xiaojia;SHANG Dewei;WEN Yuguan(Department of Pharmacy,The Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou Huiai Hospital,Guangzhou,Guangdong 510370,China)
出处
《今日药学》
CAS
2020年第6期412-414,422,共4页
Pharmacy Today
基金
广州市医药卫生科技项目(20191A011040)
广东省中医药局科研项目(20201272)。
关键词
丙戊酸盐
不良反应
临床分析
valproate
adverse reactions
clinical analysis
