摘要
目的:了解丙戊酸钠引发不良反应(adverse drug reaction,ADR)的一般规律和特点。方法:收集2011年11月—2014年11月丙戊酸钠引发的16例ADR报告,从患者性别、年龄、药物用法和用量、用药后ADR发生时间及其临床表现、转归等方面进行统计、分析。结果:丙戊酸钠引发的ADR可发生于各个年龄段,性别间无明显差异;引发ADR的主要给药途径是静脉给药,占87.50%;临床表现多见于皮疹等过敏样反应,但也可致急性暴发性肝功能损伤的严重ADR,多发生在用药30 min后。结论:临床医师、药师应了解丙戊酸钠所致ADR的规律及特点,加强监测,以减少ADR的发生。
OBJECTIVE： To investigate the general pattern and characteristics of adverse drug reaction（ ADR）induced by sodium valproate（ VPA）.METHODS： 16 cases of ADR induced by VPA reported from Nov.2011 to Nov.2014 were collected to conduct the statistical analysis in terms of the patients＇ age,gender,dosage and usage,occurrence time,clinical manifestations and outcome of ADR,etc.RESULTS： ADR induced by sodium valproate occurred in all different ages and without significant gender differences.The main route of administration that induced ADR was intravenous administration,accounting for 87.50%; the clinical manifestations of ADR were mainly rash allergic reactions,some may lead to acute fulminant liver injury,most ADR occurred more than 30 min after dosing.CONCLUSIONS： The clinicians and pharmacists should aware of the general pattern and characteristics of ADR induced by VPA.And the monitoring should be strengthened to reduce the incidence of ADR.
出处
《中国医院用药评价与分析》
2016年第2期240-242,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
丙戊酸钠
不良反应
肝功能损伤
Sodium valproate
Adverse drug reaction
Liver injury
