摘要
目的分析深圳市龙岗区埃可病毒18型引起的胃肠炎暴发疫情,为埃可病毒感染的防治工作提供科学依据。方法采用横断面研究方法了解病例发生情况及可疑传播途径,收集病例样本进行实验室检测。结果本次疫情从2019年4月19日开始至4月26日结束,持续8天,共发生病例26例,罹患率为21.14%。病例首发在小四班,且以小四班为主,占73.08%。病例的主要症状为发热(100.0%)、呕吐(84.6%)、腹痛(50.0%),大多数患者病情较轻。18份疑似患者肛拭子标本中,检出15份肠道病毒通用阳性,扩增测序得到11份埃可病毒VP1区,其中有8份为埃可病毒18型,发现其核苷酸同源性为96.6%~100.0%,基因序列未见插入或缺失,而引起本次暴发的埃可病毒18型与2015年中国山东省埃可病毒E18型分离株E18-SD15-ZZ128/SD/CHN/2015(GenBank:MG720254)同源性最高(95.80%~96.06%),亲缘关系最近。结论本次胃肠炎暴发疫情是由埃可病毒18型引起的,今后应加强对幼儿园埃可病毒感染的病原学监测和防控工作。
Objective To analyze an outbreak caused by Echovirus 18 in Longgang District of Shenzhen,and provide scientific basis for the prevention and treatment of echovirus infection.Methods A cross-sectional study of epidemiology was conducted to analyze the occurrence of the cases and suspicious transmission routes of the outbreak.Samples of anal swabs were collected for laboratory examination.Results The outbreak lasted for 8 days from April 19 to 26,2019.A total of 26 cases were diagnosed,with the attack rate of 21.14%.The cases were mainly in the fourth small class(73.08%),where the first case appeared.The main symptoms were fever(100.0%),vomit(84.6%)and abdominalgia(50.0%).Enterovirus was detected in 15 out of 18 anal swabs.VP1 genes of 11 Enterovirus strains were successfully amplified and sequenced,and 8 of them were confirmed to be Echovirus 18.Their nucleotide homology were between 96.6%to 100.0%,and there was no base deletion or insertion.Eight Enterovirus 18 strains in this study and the Shandong Province of China representative Enterovirus 18(E18-SD15-ZZ128/SD/CHN/2015),GenBank:MG720254 isolated in 2015 were showed the highest VP1 homology(nucleotide:95.80%-96.06%).Conclusion The outbreak in the kindergarten is caused by Echovirus 18.Pathogen monitoring and prevention and control of the outbreak of echovirus infection in kindergarten should be strengthened.
作者
李文东
李静媚
周健明
金玉娟
LI Wen-dong;Li Jing-mei;ZHOU Jian-ming;JIN Yu-juan(Chronic Disease Management Department,Longgang Disease Prevention and Health Care Department of Longgang District,Shenzhen Guangdong,518116,China;Department of Microbiology,Longgang Center for Disease Control and Prevention of Shenzhen,Shenzhen Guangdong,518172,China)
出处
《职业与健康》
CAS
2020年第8期1058-1061,共4页
Occupation and Health
