摘要
目的:探讨晚发性抑郁症病人同型半胱氨酸(Hcy)水平与认知功能的关系。方法:采用病例对照研究方法,对98例晚发性抑郁症病人(观察组)及88名正常老年人(对照组)进行认知功能评定,所有受试者采用酶法进行血液Hcy水平测定。结果:观察组Hcy水平高于对照组(P<0.05),各项认知功能评分均低于对照组(P<0.01)。相关性分析显示,Hcy水平与HAMD评分无相关性(P>0.05),Hcy水平与简易智力状态检查量表总分呈负相关(P<0.05)。结论:晚发性抑郁症病人存在Hcy水平的增高。与正常老年群体相比,晚发性抑郁症病人存在明显的注意、短时记忆、言语及执行功能等方面的认知功能缺陷。
Objective:To study the relationship between homocysteine(Hcy)level and cognitive function in late-onset depression.Methods:The cognitive function in 98 patients with late-onset depression(observation group)and 88 healthy olders(control group)was detected using case-control study method,and the serum levels of Hcy in two groups were enzymatically tested.Results:The Hcy level in observation group was higher than that in control group(P<0.05).The cognitive function scores in observation group were lower than that in control group(P<0.01).The results of correlation analysis showed that the Hcy level was not correlated with HAMD score(P>0.05),and the Hcy level was negatively correlated with the total score of MMSE(P<0.05).Conclusions:The levels of Hcy in patients with late-onset depression increase.Compared with the normal elderly population,the cognitive deficits in attention,short-term memory,speech,and executive function in patients with late-onset depression are obvious.
作者
陈黎明
王小泉
王祖森
CHEN Li-ming;WANG Xiao-quan;WANG Zu-sen(Graduate School,Wannan Medical College,Wuhu Anhui 241002;Deaprtment of Phychiatry,The Fourth People′s Hospital of Wuhu,Wuhu Anhui 241002,China;Department of Laboratory,The Fourth People′s Hospital of Wuhu,Wuhu Anhui 241002,China)
出处
《蚌埠医学院学报》
CAS
2020年第6期815-817,共3页
Journal of Bengbu Medical College
基金
安徽省神经精神疾病与心理健康协同创新中心开放性课题(NDMHCI-16-08)。
关键词
晚发性抑郁
同型半胱氨酸
认知功能
late-onset depression
homocysteine
cognitive function
