摘要
目的:观察苁蓉菟丝子丸联合戊酸雌二醇治疗更年期综合征(MPS)的临床疗效。方法:将64例患者随机分为对照组和治疗组,每组32例。对照组给予戊酸雌二醇治疗,治疗组在对照组的基础上联合苁蓉菟丝子丸治疗;疗程均为3个月,观察比较2组治疗前后Kupperman评分、更年期生存质量量表(MENQOL)评分;比较2组治疗前后血清雌二醇(E2)、促卵泡激素(FSH)水平变化;比较2组总体临床疗效。结果:总有效率治疗组为93.75%,对照组为71.88%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组患者Kupperman评分均较治疗前明显降低(P<0.05),且治疗组评分低于对照组(P<0.05)。治疗后,2组患者心理维度、生理维度、血管舒缩维度等MENQOL评分均较治疗前降低(P<0.05),且治疗组各项评分均明显低于对照组(P<0.05)。治疗后,2组患者血清E2水平均较治疗前升高(P<0.05),FSH水平均较治疗前降低(P<0.05);且治疗组项指标改善较对照组更显著(P<0.05)。结论:苁蓉菟丝子丸联合戊酸雌二醇治疗MPS疗效显著,效果优于单纯西药治疗。
Objective:To observe the clinical effect of Congrong Tusizi pills combined with estradiol valerate for menopausal syndrome(MPS).Methods:Divided 64 cases of patients into the control group and the treatment group randomly,32 cases in each group.The control group received estradiol valerate,while the treatment group additionally received Congrong Tusizi pills.The courses of treatment in both groups lasted for 3 months.Observed and compared the scores of Kuppermanand Menopausal Quality of Life Scale(MENQOL)in both groups before and after treatment;compared the changes in levels of serum estradiol(E2)and follicle stimulating hormone(FSH)in both groups before and after treatment;compared the overall clinical effect between the two groups.Results:The total effective rate was 93.75%in the treatment group and 71.88%in the control group,difference being significant(P<0.05).After treatment,Kupperman scores in both groups were significantly lower than those before treatment(P<0.05),and Kupperman scores in the treatment group were lower than those in the control group(P<0.05).After treatment,the scores of MENQOL Scale in psychological dimension,physiological dimension and vasomotion dimension in both groups were respectively lower than those before treatment(P<0.05),and each score of MENQOL Scale abovein the treatment group was significantly lower than that in the control group(P<0.05).After treatment,the levels of serum E2 in both groups were higher than those before treatment(P<0.05),and the levels of FSH were lower than those before treatment(P<0.05);each index in the treatment group was improved more obviously than that in the control group(P<0.05).Conclusion:The application of Congrong Tusizi pills combined with estradiol valerate has significant clinical effect in treating MPS,and has better clinical effect than simple western medicine therapy.
作者
史馨莹
张明
徐静瑶
SHI Xinying;ZHANG Ming;XU Jingyao
出处
《新中医》
CAS
2020年第10期90-92,共3页
New Chinese Medicine
关键词
更年期综合征
中西医结合疗法
苁蓉菟丝子丸
戊酸雌二醇
Menopausal syndrome
Integrated Chinese and western medicine therapy
Congrong Tusizi pills
Estradiol valerate
