摘要
目的探讨肾功能、炎症及凝血指标与非瓣膜性心房颤动(NVAF)合并脑卒中的相关性,寻找非瓣膜性心房颤动合并脑卒中的独立危险因素。方法纳入于2018-08-10-2019-10-30入住安徽省立医院非瓣膜性心房颤动的患者214例,按患者是否合并脑卒中分为单纯心房颤动组和心房颤动合并脑卒中组,记录患者相关资料,如一般情况、既往史等,同时测量2组肾功能、凝血象、心功能等相关指标,记录出院时情况,对比2组相关指标,筛选出NVAF伴脑卒中的相关因素,差异有统计学意义指标进行Logistic回归分析。结果NVAF合并脑卒中组129例,年龄(74.46±9.78)岁;NVAF合并脑卒中组年龄、既往抗凝史、C反应蛋白(CRP)、超敏C反应蛋白、胱抑素C、肌钙蛋白I、BNP、纤维蛋白原、D-二聚体水平较未合并组明显升高,差异有统计学意义(P<0.05)。二元Logistic回归分析示,超敏C反应蛋白、胱抑素C、D-二聚体是NVAF合并脑卒中的危险因素(P<0.05);与疾病严重程度明显相关的因素为NT-proBNP、纤维蛋白原(P<0.05)。结论超敏C反应蛋白、胱抑素C、D-二聚体为NVAF合并脑卒中的独立危险因素,NT-proBNP及纤维蛋白原水平与合并脑卒中疾病严重程度具有相关性。
Objective To explore the correlation of renal function,inflammation and coagulation with non valvular atrial fibrillation(NVAF)with stroke,and to find the independent risk factors of NVAF with stroke.Methods Patients with NVAF who were admitted to Anhui provincial hospital from August 10,2018 to October 30,2019 were enrolled.They were divided into two groups according to whether the patients were combined with strokethe simple NVAF and the NVAF combined with stroke.The relevant data of the patients were recorded,such as the general situation and past history of the patients.Meanwhile,the renal function,coagulation,cardiac function and other related indexes of the two groups were measured.The related factors of NVAF with stroke were screened out by comparing the two groups of related indexes,and the significant indexes were analyzed by Logistic regression.Results 129 patients in the NVAF combined stroke group,aged(74.46±9.78)years;NVAF combined with stroke group age,previous anticoagulation history,C reactive protein(CRP),hypersensitive C reactive protein,cystatin C,troponin I,BNP,fibrinogen,D-dimer levels were significantly higher than the non-combined group,the difference was statistically significant(P<0.05).Binary Logistics regression analysis showed that high-sensitivity C-reactive protein,cystatin C,and D-dimer are risk factors for NVAF combined with stroke(P<0.05);the risk factors that are significantly related to the severity of the patient's disease are NT-proBNP,fibrinogen(P<0.05).Conclusion High sensitive C-reactive protein,Cystatin C and D-dimer are independent risk factors of NVAF with stroke.NT proBNP and fibrinogen levels are correlated with the severity of the stroke.
作者
吴旱淋
潘亭
汤其强
WU Hanlin;PAN Ting;TANG Qiqiang(Anhui Provincial Hospital,Hefei 230001,China)
出处
《中国实用神经疾病杂志》
2020年第11期921-925,共5页
Chinese Journal of Practical Nervous Diseases
基金
国家自然科学基金面上项目(编号:81573807)。
关键词
脑卒中
心房颤动
肾功能损害
D-二聚体
超敏C反应蛋白
Stroke
Atrial fibrillation
Impairment of renal function
D-dimer
Hypersensitive C-reactive protein
