摘要
目的 系统评价中国人群卒中后认知障碍(PSCI)患者的危险因素,以期为PSCI风险预测模型的建立提供参考依据。方法 检索万方数据、维普期刊网、中国知网、PubMed、The Cochrane Library、Embase数据库从建库至2022年9月1日有关研究中国人群急性缺血性脑卒中患者发生认知障碍危险因素的所有文献,采用RevMan 5.4和Stata 12.0软件进行Meta分析。结果 共纳入文献34篇,研究对象12 365例。Meta分析结果显示,中国缺血性脑卒中人群中PSCI的发病率为50%。男性(OR=0.76,95%CI 0.63~0.92)、年龄大(WMD=5.44,95%CI 4.25~6.62)、文化程度低(OR=2.43,95%CI 1.86~3.17)、NIHSS评分高(WMD=3.08,95%CI 1.15~5.00)、高血压(OR=1.61,95%CI 1.37~1.89)、糖尿病(OR=1.33,95%CI 1.15~1.53)、脑卒中既往史(OR=2.73,95%CI 1.83~4.08)、糖化血红蛋白≥6%(OR=4.04,95%CI 2.67~6.10)、低密度脂蛋白胆固醇高(WMD=0.13,95%CI 0.03~0.23)、同型半胱氨酸高(WMD=3.92,95%CI 2.16~5.68)、高敏C反应蛋白高(WMD=2.35,95%CI 0.39~4.30)、胱抑素C高(WMD=0.22,95%CI 0.09~0.34)是中国PSCI患者的危险因素(P<0.05)。结论 多种因素相互作用影响PSCI的发生,通过定期检查相关化验指标、控制治疗合并疾病等干预措施,有望降低PSCI的发生率。
Objective To systematically evaluate the risk factors of Chinese people with post stroke cognitive impairment(PSCI), so as to provide a reference for the establishment of PSCI risk prediction model. Methods We searched Wanfang Data, Weipu Journal Network, CNKI, PubMed, The Cochrane Library, and Embase databases from the establishment of the database to September 1, 2022, and used RevMan 5.4 and Stata 12.0 software for meta-analysis. Results A total of 34 articles were included, including 12 365 subjects. Meta analysis showed that the incidence rate of PSCI in Chinese ischemic stroke population was 50%. Male(OR=0.76, 95% CI 0.63-0.92), age(WMD=5.44,95% CI 4.25-6.62), low education level(OR=2.43, 95% CI 1.86-3.17), NIHSS score(WMD=3.08, 95% CI 1.15-5.00), hypertension(OR=1.61, 95% CI 1.37-1.89), diabetes(OR=1.33, 95% CI 1.15-1.53), past history of stroke(OR=2.73, 95% CI 1.83-4.08), glycosylated hemoglobin ≥ 6%(OR=4.04, 95% CI 2.67-6.10) Low density lipoprotein cholesterol(WMD=0.13, 95% CI 0.03-0.23), homocysteine(WMD=3.92, 95% CI 2.16-5.68), high-sensitivity C-reactive protein(WMD=2.35, 95% CI 0.39-4.30), and cystatin C(WMD=0.22, 95% CI 0.09-0.34) were risk factors for PSCI patients in China(P<0.05). Conclusion Multiple factors interact to affect the occurrence of PSCI. It is expected to reduce the incidence of PSCI through regular inspection of relevant laboratory indicators, control and treatment of combined diseases and other interventions.
作者
赵万年
焦胜先
焦倩
李沙沙
贾亚晴
王贺波
Zhao Wannian;Jiao Shengxian;Jiao Qian;Li Shasha;Jia Yaqing;Wang Hebo(School of Graduate,Hebei Medical University,Hebei Province,Shijiazhuang 050000,China;不详)
出处
《疑难病杂志》
CAS
2023年第1期82-89,共8页
Chinese Journal of Difficult and Complicated Cases
基金
河北省自然科学基金重点项目(H2020307041)。
