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普拉洛芬滴眼液联合小牛血去蛋白提取物眼用凝胶治疗中重度干眼症的临床效果 被引量:13

Clinical effect of pranoprofen eye drops combined with deproteinized calf blood extract eye gel in the treatment of moderate and severe xerophthalmia
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摘要 目的分析普拉洛芬滴眼液联合小牛血去蛋白提取物眼用凝胶治疗中重度干眼症的临床效果。方法选取我院收治的100例中重度干眼症患者作为研究对象,随机将其分为对照组(50例,普拉洛芬滴眼液治疗)和观察组(50例,普拉洛芬滴眼液+小牛血去蛋白提取物眼用凝胶治疗)。比较两组患者的治疗效果。结果观察组的治疗总有效率显著高于对照组(P<0.05)。治疗后,两组的溶菌酶、LF、TGF-β2、EGF水平均升高,且观察组明显高于对照组(P<0.05)。治疗后,两组的OSDI评分均下降,NEI-VFQ-25各项评分均升高,且观察组均优于对照组(P<0.05)。结论普拉洛芬滴眼液联合小牛血去蛋白提取物眼用凝胶治疗中重度干眼症的临床效果显著,够有效改善患者干眼症状和泪液相关指标水平,提高患者视觉功能。 Objective To analyze the clinical effect of pranoprofen eye drops combined with deproteinized calf blood extract eye gel in the treatment of moderate and severe xerophthalmia.Methods A total of 100 patients with moderate and severe xerophthalmia admitted in our hospital were selected as the research objects,and the patients were randomly divided into control group(50 cases,pranoprofen eye drops treatment)and observation group(50 cases,pranoprofen eye drops+deproteinized calf blood extract eye gel treatment).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the levels of lysozyme,LF,TGF-β2 and EGF in the two groups increased,and those in the observation group were significantly higher than the control group(P<0.05).After treatment,the OSDI scores in the two groups decreased,the NEI-VFQ-25 scores increased,and those in the observation group were better than the control group(P<0.05).Conclusion Pranoprofen eye drops combined with deproteinized calf blood extract eye gel in the treatment of moderate and severe xerophthalmia has a significant clinical effect.It can effectively improve dry eye symptoms,related indexes levels of tear and the visual function of patients.
作者 杨守红 邬启林 YANG Shou-hong;WU Qi-lin(Affiliated Hospital of Shangluo Vocational and Technical College,Shangluo 726000,China)
出处 《临床医学研究与实践》 2020年第18期97-99,共3页 Clinical Research and Practice
关键词 普拉洛芬滴眼液 小牛血去蛋白提取物眼用凝胶 中重度干眼症 pranoprofen eye drops deproteinized calf blood extract eye gel moderate and severe xerophthalmia
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