摘要
目的:基于数据挖掘方法探究痛风患者的同型半胱氨酸(Hcy)与炎性反应、免疫、代谢指标的相关性、关联性及危险因素。方法:选取、整理2012年6月至2018年6月在安徽省中医院风湿科就诊的住院痛风患者病例资料,研究其同型半胱氨酸(Hcy)与炎性反应指标:超敏C反应蛋白(hs-CRP);免疫指标:免疫球蛋白A、M、G(IgA、IgG、IgM)、补体C3、补体C4;代谢指标:甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、尿酸(UA)、α1酸性糖蛋白(α1-AGP)。运用SPSS 22.0、SPSS Clementine 11.1 Aprior等统计学软件对指标进行相关性分析、关联性分析、二元Logistics回归分析。结果:①共纳入GOUT患者158例。②相关性分析显示:Hcy与IgG呈负相关(P<0.05),与UA呈正相关(P<0.05),与其余项差异无统计学意义。③经关联性分析:Hcy升高与C3、α1-AGP、Hs-CRP、TC、LDL、IgG升高呈强关联。④二元Logistic回归分析得出,Hcy与LDL呈正相关(P<0.05),与补体C4呈负相关(P<0.05),与其他指标不相关(P>0.05)。结论:痛风患者的Hcy的升高与炎性反应、免疫、代谢指标的升高具有相关性,重点发现Hcy多与脂代谢、UA异常有相关性,参与了痛风的发病及活动,具体机制有待进一步研究。
Objective:To investigate the correlation and relationship of homocysteine(Hcy)with immune-inflammatory and metabolic indexes,and the risk factors in patients with gout based on data mining approach.Methods:The medical record data of gouty patients who stayed in the Rheumatology Department of Anhui Hospital of Traditional Chinese Medicine between June 2012 and June 2018 were retrieved for investigation on the profiles of Hcy and immune-inflammatory indexes which included high sensitive C-reactive protein(hs-CRP),immunological indexes[immunoglobulins A,M,and G(IgA,IgG,IgM),complements C3 and C4],metabolic indexes[triglyceride(TG),total cholesterol(TC),high-density lipoprotein(HDL),low-density lipoprotein(LDL),uric acid(UA),andα1 acid glycoprotein(α1-AGP)].Statistical software,including SPSS version 22.0 and SPSS Clementine 11.1 Aprior,were used for correlation and relationship analyses,and binary logistic regression.Results:(1)A total of 158 gouty patients were included.(2)Correlation analysis showed that Hcy was correlated negatively with IgG(P<0.05),positively with UA(P<0.05),and was no statistically significant difference with other indexes(P<0.01).(3)Relationship analysis showed that elevated Hcy was strongly associated with increased levels of C3,α1-AGP,Hs-CRP,TC,LDL and IgG.(4)Binary logistic regression showed that Hcy was correlated positively with LDL(P<0.05),negatively with complement C4(P<0.05),but not with the other indexes(P>0.05).Conclusion:The Hcy elevation in patients with gout is related to the increase in inflammatory response,immunity and metabolic indicators.Importantly,Hcy is mostly related to dyslipidemia and UA metabolic abnormalities,pending further study on the exact mechanism.
作者
孙广瀚
刘健
龙琰
鲍丙溪
张颖
Sun Guanghan;Liu Jian;Long Yan;Bao Bingxi;Zhang Ying(Graduate School,Anhui University of Traditional Chinese Medicine;Anhui Provincial Hospital of Traditional Chinese Medicine,Hefei 230038,Anhui,China)
出处
《广州医科大学学报》
2020年第2期31-34,共4页
Academic Journal of Guangzhou Medical University
基金
国家自然基金青年项目(81403388)
2016年中央引导地方科技发展专项(财教[2016]1188)
现代中医内科应用基础与开发研究安徽省重点实验室(财教[2016]518)
安徽高校自然科学研究重点项目(KJ2017A281)
国家自然基金项目(81503558)。
