摘要
目的探讨耳穴埋针联合针灸治疗围绝经期不寐的临床效果。方法选取2017年12月~2019年6月于黑龙江中医药大学附属第一医院针灸科门诊及住院处收治的100例围绝经期不寐患者,采用随机数字表法将其分为观察组(50例)和对照组(50例)。观察组采用揿针耳穴埋针联合针灸治疗,对照组采用艾司唑仑治疗。观察两组治疗前后的血清雌激素(E2)、卵泡刺激素(FSH)、5-羟色胺(5-HT)、去甲肾上腺素(NE)水平及匹兹堡睡眠质量指数(PSQI)睡眠时间评分、总分。结果两组治疗后PSQI睡眠时间评分及总分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05或P<0.01)。两组治疗后血清E2水平均高于治疗前,且观察组高于对照组;两组治疗后血清FSH水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05或P<0.01)。两组治疗后血清5-HT水平均高于治疗前,且观察组高于对照组;两组治疗后血清NE水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05或P<0.01)。结论耳穴埋针联合针灸治疗可以改善围绝经期患者的睡眠质量,可能与其促进血清E2、5-HT的表达与抑制血清FSH、NE的表达密切相关。
Objective To explore clinical effect of auricular acupoint embedding combined with acupuncture in the treatment of perimenopausal insomnia.Methods From December 2017 to June 2019,100 cases of perimenopausal insomnia were selected from the Outpatient Department and Inpatient Department of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine.They were divided into observation group(50 cases)and control group(50 cases)by random number table method.Observation group was treated by pressing auricular point and embedding acupuncture combined with acupuncture,while control group was treated by Estazolam.The levels of serum estrogen(E2),follicle stimulating hormone(FSH),5-hydroxytryptamine(5-HT),noradrenaline(NE),sleep time and total scores of Pittsburgh sleep quality index(PSQI)were observed before and after treatment in two groups.Results The scores of sleep time and total scores of PSQI after treatment of two groups were lower than those before treatment,which of observation group were lower than those of control group,the differences were statistically significant(P<0.05 or P<0.01).The serum E2 level of two groups after treatment was higher than that before treatment,and that of observation group was higher than that of control group;the serum FSH levels of two groups after treatment were lower than those before treatment,and that of observation group was lower than that of control group,the differences were statistically significant(P<0.05 or P<0.01).The serum 5-HT levels of two groups after treatment were higher than those before treatment,and that of observation group was higher than that of control group;the levels of serum NE after treatment in two groups were lower than those before treatment,and that in observation group was lower than that in control group,the differences were statistically significant(P<0.05 or P<0.01).Conclusion Auricular acupuncture embedding combined with acupuncture can improve the sleep quality of perimenopausal patients by promoting the expression of serum E2,5-
作者
杨月
邹鹏
高惠宁
YANG Yue;ZOU Peng;GAO Huining(The Second Department of Cardiology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China;Department of Hematology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China;Room of Endoscopy,the Third Affiliated Hospital of Harbin Medical University,Heilongjiang Province,Harbin150030,China)
出处
《中国医药导报》
CAS
2020年第15期143-146,共4页
China Medical Herald
基金
教育部“春晖计划”合作科研项目(Z2010019)
黑龙江省中医药科研项目(ZHY19-010)。
关键词
耳穴埋针
针灸
围绝经期
不寐
Auricular acupoint embedding
Acupuncture
Perimenopausal
Insomnia
