摘要
射血分数保留型心力衰竭(HFpEF)的患病率正在逐年上升,HFpEF的特点是左室舒张压升高,病理生理改变是心肌肥大以及进行性心肌纤维化和心肌细胞硬度增加。心肌纤维化与HFpEF密切相关。目前HFpEF诊断标准仍然存在争议,既往主要依赖于超声心动图对左心室舒张功能和充盈压力进行评价,近年来研究发现脑利钠肽和可溶性基质裂解素2(sST2)诊断HFpEF敏感度和特异性尚可。本综述从心肌纤维化及其检测方法着手,论述sST2在HFpEF患者中的变化及意义、sST2与BNP联合检测对于HFpEF诊断价值、预后判断及对于临床的指导作用。
The prevalence of heart failure with preserved ejection fraction(HFpEF)is increasing.HFpEF is characterized by increased left ventricular diastolic blood pressure,and pathophysiological changes are myocardial hypertrophy,progressive myocardial fibrosis,and increased myocardial cell hardness.Myocardial fibrosis is closely related to HFpEF.At present,HFpEF diagnostic criteria are still controversial and used to mainly rely on echocardiographic to evaluate left ventricular diastolic sfunction and filling pressure.In recent years,studies have found that the sensitivity and specificity of brain natriuretic peptide and soluble tumorigenic source2(sST2)are satisfactory in the diagnosis of HFpEF.This review starts with myocardial fibrosis and its detection methods and discusses the changes and significance of sST2 in HFpEF patients,the diagnostic value,prognostic judgment and clinical guidance of sST2 combined with BNP for HFpEF.
作者
郭晓
王肖龙
汤仁智
孙元隆
李益萍
肖正达
阮小芬
GUO Xiao;WANG Xiaolong;TANG Renzhi;SUN Yuanlong;LI Yiping;XIAO Zhengda;RUAN Xiaofen(Department of Geriatric Medicine,Shanghai Yingkang Nursing Hospital,Shanghai201712,China;Department of Cardiovascular,Shuguang Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai201203,China)
出处
《中国医药导报》
CAS
2020年第15期29-33,共5页
China Medical Herald
基金
国家自然科学基金资助项目(81573647、81403352)
上海申康医院发展中心市级医院临床研究培育项目(SHDC12018X29)
上海市高级中西医结合人才培养项目[ZY(2018-2020)-RCPY-2004]
上海市中医临床重点实验室(14DZ2273200)。
关键词
心力衰竭
射血分数保留
可溶性基质裂解素2
脑利钠肽
Heart failure
Preserved ejection fraction
Soluble tumorigenic source 2
Brain natriuretic peptide
