摘要
目的分析金黄色葡萄球菌耐药率与抗菌药物使用量的相关性,为临床合理使用抗菌药物提供参考依据。方法回顾性分析该院2014~2018年8类抗菌药物的用药频度和金黄色葡萄球菌的耐药率情况,采用Pearson相关分析法分析各类抗菌药物限定日剂量累积数(DDDs)与金黄色葡萄球菌耐药率的相关性。结果金黄色葡萄球菌的青霉素耐药率与第3代头孢菌素(r=0.912)和喹诺酮类(r=0.940)抗菌药物的DDDs呈正相关(P<0.05)。苯唑西林耐药率与含酶抑制剂复方制剂的DDDs呈正相关(r=0.902,P<0.05)。金黄色葡萄球菌对左氧氟沙星的耐药率与第1代头孢菌素(r=0.949)以及大环内酯类(r=0.861)抗菌药物的DDDs呈高度正相关(P<0.05),与含酶抑制剂复方制剂DDDs呈高度负相关(r=-0.852,P<0.05)。克林霉素耐药率与第1代头孢菌素抗菌药物DDDs呈高度正相关(r=0.921,P<0.05)。结论抗菌药物的DDDs与金黄色葡萄球菌的耐药率之间存在一定的相关性且关系复杂。
Objective To investigate the correlation between the drug-resistant rate of Staphylococcus aureus and the consumption of antibacterial agents,and to provide a reference for the rational use of antibacterial agents in clinical practice.Methods A retrospective analysis of the frequency of use of eight types of antibacterial agents and the drug-resistant rate of Staphylococcus aureus was performed in our hospital from 2014 to 2018,and the correlation between the antibacterial drug cumulative defined daily doses(DDDs)and the drug-resistant rate of Staphylococcus aureus was analyzed using Pearson correlation analysis.Results The penicillin resistance rate of Staphylococcus aureus was positively correlated with DDDs of the third-generation cephalosporins(r=0.912)and quinolones(r=0.940)antibacterials(P<0.05).The rate of oxacillin resistance was positively correlated with DDDs of the compound preparations containing enzyme inhibitors(r=0.902,P<0.05).The resistance rate of Staphylococcus aureus to levofloxacin was highly positively correlated with DDDs of the first-generation cephalosporins(r=0.949)and macrolides(r=0.861)antibacterials(P<0.05),and was highly negatively correlated with DDDs of the compound preparations containing enzyme inhibitors(r=-0.852,P<0.05).The clindamycin resistance rate were highly positively correlated with DDDs of the first-generation cephalosporins(r=0.921,P<0.05).Conclusion There is a certain correlation and complex relationship between DDDs of antibacterial agents and drug-resistance rates of Staphylococcus aureus.
作者
彭芳
孙夫东
叶新民
许宝华
孟超
PENG Fang;SUN Fu-dong;YE Xin-min(Department of Clinical Pharmacy,the People′s Hospital of Pingyi County,Shandong 273300,China)
出处
《中国临床新医学》
2020年第5期491-495,共5页
CHINESE JOURNAL OF NEW CLINICAL MEDICINE
基金
江西省重点实验室计划项目(编号:20192BCD40003)。
关键词
金黄色葡萄球菌
耐药率
抗菌药物
相关性
Staphylococcus aureus
Drug-resistant rate
Antibacterial agents
Correlation
