摘要
目的:探讨复方黄藤合剂对急性放射性肠炎(ARE)的防治效果及对血清炎症因子的调节作用。方法:将140例患者随机分为对照组和观察组各70例。对照组采用精确放射治疗,并口服蒙脱石散,3 g/次,3次/d。观察组放疗同期口服复方黄藤合剂,1剂/d。两组疗程均至放疗结束后2周。记录ARE(1级和2级)出现的时间和照射剂量,记录重度ARE(3级和4级)发生率;放疗结束后2周进行内镜评估,ARE症状评分和生活质量KPS评分;检测治疗前后血清白细胞介素-1(IL-1),IL-4,IL-6,肿瘤坏死因子-α(TNF-α)和C反应蛋白(CRP)水平。结果:观察组患者1级和2级ARE出现时间均短于对照组(P<0.01),出现1级和2级ARE时的照射剂量均多于对照组(P<0.01);在放疗4,5周和放疗结束后2周,观察组2级及以上ARE发生率分别为42.86%(30/70),50.00%(35/70)和54.29%(38/70),均低于同期对照组的61.43%(43/70),68.57%(48/70)和74.29%(52/70)(χ^2=4.837,P<0.05;χ^2=5.001,P<0.05;χ^2=6.097,P<0.05);观察组患者放疗后ARE发生率为62.86%(44/70),低于对照组的78.57%(55/70)(χ^2=4.173,P<0.05);观察组患者重度ARE发生率13.64%(6/44),低于对照组的32.73%(18/55)(χ^2=4.851,P<0.05);观察组患者放疗后内镜评分和ARE症状评分均低于对照组,KPS评分高于对照组(P<0.01);放疗后观察组患者血清IL-1,IL-6,TNF-α和CRP水平低于对照组(P<0.01),IL-4水平高于对照组(P<0.01)。结论:采用复方黄藤合剂同期用于放疗患者能降低ARE发生率,推迟了ARE出现,减轻了ARE发生程度,并能调节炎症因子表达,减轻了临床症状,提高了患者生活质量,从而有利于放疗的顺序开展。
Objective:To discuss the efficacy of compound Huangteng mixture for acute radiation enteritis(ARE)and to investigate its regulatory effect on serum inflammatory factors.Method:One hundred and forty patients were randomly divided into control group(70 cases)and observation group(70 cases)by random number table.Patients in control group got precise radiotherapy.And take montmorillorillonite powder orally based on the treatment in control group,patients in observation group additionally received compound Huangteng mixture,1 dose/day.The treatment was continued to the second week after the ending of radiotherapy in both groups.Time of appearance of ARE(1 and 2 levels),irradiation dose and incidence of severe ARE(3 and 4 levels)were recorded.Endoscope examination was conducted at the second week after the ending of radiotherapy.ARE symptom scores and KPS scores of quality of life were graded.Levels of serum interleukin-1(IL-1),IL-4,IL-6,tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)were detected both before and after treatment.Result:Time of appearance of ARE(1 and 2 levels)in observation group was shorter than those in control group(P<0.01),and irradiation dose was more than that in control group(P<0.01).At the fourth and fifth week of radiotherapy and at the second week after the ending of radiotherapy,incidence rate of ARE(levels 2 and above)was 42.86%(30/70),50.00%(35/70)and 54.29%(38/70),all lower than 61.43%(43/70),68.57%(48/70)and 74.29%(52/70)in control group(χ^2=4.837,P<0.05,χ^2=5.001,P<0.05,χ^2=6.097,P<0.05).After radiotherapy,incidence of ARE was 62.86%(44/70)in observation group,lower than 78.57%(55/70)in control group(χ^2=4.173,P<0.05),and the incidence of severeARE was 13.64%(6/44)in observation group,lower than 32.73%(18/55)in control group(χ^2=4.851,P<0.05).Scores of endoscope and ARE symptoms in observation group were lower than those in control group,while score of KPS was higher than that in control group(P<0.01).After radiotherapy,levels of IL-1,IL-6,TNF-αand CRP in observation g
作者
姚诗清
何斌
孙蕊
柳雯
孙涛
周兰
YAO Shi-qing;HE Bin;SUN Rui;LIU Wen;SUN Tao;ZHOU Lan(The First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2020年第9期69-74,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
安徽省卫生厅中医药管理局项目(2014zy25)
2018年度蚌埠医学院科技发展基金项目(BYKF1860)。
关键词
急性放射性肠炎
复方黄藤合剂
放射治疗
预防
炎症因子
acute radiation enteritis
compound Huangteng mixture
radiotherapy
prevention
inflammatory factors
