摘要
目的 观察参苓白术散防治放射性肠炎方面的功效。方法 将 5 6例妇科肿瘤 (子宫颈癌、子宫内膜癌 )随机分成 2组 ,一组为中药加放疗组 (以下简称为观察组 ,3 0例 ) ,另一组为单纯放疗组 (以下简称为对照组 ,2 6例 )。 2组外照射总剂量 48～ 5 0Gy/5～ 6周 ,180～ 2 0 0cGy/次 ,5次 /周。后装治疗 :宫颈癌总剂量 42～ 49Gy/6～ 7周 ,子宫内膜癌总剂量 10～ 15Gy/1～ 2周。观察组在放疗期间 ,服用参苓白术散。观察 2组放射性肠炎发生情况。结果 放疗 1年后 ,行纤维结肠镜检查 ,2组患者放射性肠炎发生情况 ,观察组共发生 13例 ( 4 3 .3 % ) ,其中Ⅰ度为 10例 ,Ⅱ度为 2例 ,Ⅲ度为 1例 ;对照组共发生 2 5例 ( 96.2 % ) ,其中Ⅰ度为 8例 ,Ⅱ度为 8例 ,Ⅲ度为 9例 ,2组比较有显著性差异 (P <0 .0 5 )。
Objective To study the effect of traditional Chinese medicine Shenlingbaishusan in preventing and treating radiation enteritis.Methods Fifty-six patients with female pelvic tumor(cervix carcinoma and endometrial cancer) were randomly divided into two groups:the radiotherapy(RT) alone group(26 cases) and the RT+ Shenlingbaishusan group(30 cases).RT in both groups was similar,they were all received 1.8～2.0 Gy/per fraction,five fractions/per week,with the total dose of 48～50 Gy/5～6 weeks to whole pelvis external irradiation and brachytherapy to a total dose of 42～49 Gy/6～7 weeks in cervix carcinoma and 10～15 Gy/1～2 weeks in endometrial cancer.Results All patients were followed up for more than one year after radiotherapy.The incidence of acute and late radiation enteritis rate was 43.3%(13 cases) in the RT+ Shenlingbaishusan group:Ⅰgrade 10 cases,Ⅱgrade 2 cases,Ⅲgrade 1 case,96.2%(25 cases) in the RT group:Ⅰgrade 8 cases,Ⅱgrade 8 cases,Ⅲgrade 9 cases(P<0.05).Conclusion The traditional Chinese medicine Shenlingbaishusan was effective in preventing and treating radiation enteritis in pelvic tumor radiotherapy.
出处
《实用癌症杂志》
2004年第3期317-318,共2页
The Practical Journal of Cancer
基金
深圳市科技局资助课题 (No .2 0 0 1 0 4 0 69)
关键词
盆腔肿瘤
放疗
参苓白术散
防治措施
放射性肠炎
Traditional chinese medicine
Shenlingbaishusan
Radiotherapy
Pelvic tumor
Radiation enteritis
