摘要
目的探讨激素替代治疗在围绝经期综合征患者中的应用价值。方法选取2017年11月~2019年1月我院收治的80例围绝经期综合征妇女作为研究对象,按照随机数字表法将其分为观察组(40例)与对照组(40例)。对照组患者实施对症支持处理,口服谷维素片及坤泰胶囊。观察组患者应用戊酸雌二醇片,结合使用醋酸甲羟孕酮分散片治疗。两组患者均连续治疗6个疗程,作为1个治疗周期。在治疗满1个周期后,对所有入组者门诊随访3个月。比较两组患者干预后3个月的女性性生活质量标准指标量表(FSFI)得分情况;比较两组患者干预后3个月的性激素水平变化情况,如雌二醇(E2)、卵泡刺激素(FSH)及黄体生成素(LH);统计两组患者随访过程中烦躁、疲乏、失眠、性生活异常、潮热等临床症状的发生率;比较两组患者干预前及干预后1、3个月的总胆固醇水平变化情况。结果干预后3个月,观察组的FSFI各项评分及总分高于对照组,差异有统计学意义(P<0.05);干预后3个月,观察组的E2水平高于对照组,LH和FSH水平低于对照组,差异均有统计学意义(P<0.05);随访期间,观察组患者的烦躁、疲乏、失眠、性生活异常、潮热等临床症状发生率均低于对照组,差异有统计学意义(P<0.05);干预后1、3个月,两组患者的总胆固醇水平均低于本组干预前,且观察组患者的总胆固醇水平低于对照组,差异有统计学意义(P<0.05)。结论针对围绝经综合征,在应用戊酸雌二醇片基础上结合使用醋酸甲羟孕酮分散片治疗,能有效改善患者的性生活质量,调节性激素水平,改善临床症状,降低血脂水平。
Objective To explore the application value of hormone replacement therapy in patients with perimenopausal syndrome. Methods A total of 80 women with perimenopausal syndrome admitted in our hospital from November 2017 to January 2019 were selected as subjects. According to the random number table method, they were divided into observation group(40 cases) and control group(40 cases). Patients in the control group were given symptomatic support treatment, orally administered with Guweisu Tablets and Kuntai Capsules. Patients in the observation group were treated with Estradiol Valerate Tablets combination with Medroxyprogesterone Acetate Dispersive Tablets. Patients in both groups were treated continuously for 6 courses of treatment, as one treatment cycle. After 1 cycle of treatment, all participants were followed up in the outpatient department for 3 months. The scores of female sexual life quality standard indicator scale(FSFI) at 3 months after intervention were compared between the two groups. Changes in levels of sex hormones, such as estradiol(E2), follicle-stimulating hormone(FSH) and luteinizing hormone(LH), at 3 months after intervention were compared between the two groups. The incidence of clinical symptoms such as irritability, fatigue, insomnia, abnormal sex life and hot flashes during the follow-up of the two groups were calculated. The changes of total cholesterol levels before and after intervention were compared between the two groups. Results Three months after intervention, FSFI scores and total score of the observation group were higher than those of the control group, with statistically significant differences(P<0.05). Three months after intervention, the E2 level of the observation group was higher than that of the control group, and the LH and FSH levels were lower than those of the control group, with statistically significant differences(P<0.05). During the follow-up, the incidences of clinical symptoms such as irritability, fatigue,insomnia, abnormal sex life and hot flashes in the observa
作者
邓新
任冉
DENG Xin;REN Ran(Department of Gynecology,Dalian Maternity Hospital,Liaoning Province,Dalian116033,China)
出处
《中国当代医药》
2020年第11期126-129,共4页
China Modern Medicine
关键词
激素替代
围绝经期综合征
临床症状
血脂水平
Hormone replacement
Perimenopausal syndrome
Clinical symptoms
Blood lipid level
