摘要
目的:探讨补肾疏肝汤治疗围绝经期综合征肾虚肝郁证患者的效果及其对血清促卵泡生成素(FSH)、促黄体生成素(LH)、雌二醇(E2)的影响。方法:将2022年5月—2022年10月福建医科大学附属闽东医院诊治的76例围绝经期综合征肾虚肝郁证患者,按随机双盲法分为观察组和对照组,每组38例。对照组进行激素补充治疗,口服雌二醇片/雌二醇地屈孕酮片,28 d为1个疗程,前14 d每天口服白片1片,每片白片含1 mg雌二醇,后14 d每天口服灰片1片,每片灰片含1 mg雌二醇和10 mg地屈孕酮。观察组应用补肾疏肝汤联合激素补充治疗,共治疗3个月经周期,观察临床疗效及患者血清FSH、LH、E2水平的变化,记录药物不良反应。结果:观察组治疗后总有效率(89.47%)与对照组(68.42%)比较,差异有统计学意义(P<0.05)。经治疗后,观察组的性激素水平(FSH、LH、E2)及中医症状积分明显优于对照组,差异有统计学意义(P<0.05,P<0.01)。在治疗过程中,观察组乳房胀痛、阴道不规则出血、消化不良的发生率和不良反应的总发生率均低于对照组,差异均有统计学意义(P<0.05)。结论:相对于单纯激素替代疗法,联合补肾疏肝汤可有效改善围绝经期综合征肾虚肝郁证患者的卵巢功能,减轻症状,且安全性高。
Objective:To explore the effect of Bushen Shugan Decoction in the treatment of perimenopausal syndrome patients with kidney deficiency and liver depression and its effect on serum follicle stimulating hormone(FSH),luteinizing hormone(LH)and estradiol(E2).Methods:76 perimenopausal syndrome patients with kidney deficiency and liver depression who were diagnosed and treated in Mindong Hospital Affiliated to Fujian Medical University from May 2022 to October 2022 were divided into the observation group and the control group according to the random double-blind method,with 38 cases in each group.The patients in the control group were treated with hormone replacement therapy,taking complex packing estradiol tablets/estradiol and dydrogesterone tablets orally for 28 days as a course of treatment.For the first 14 days,one white tablet was taken orally every day,with each white tablet containing 1 mg of estradiol.For the last 14 days,one gray tablet was taken orally every day with each gray tablet containing 1 mg of estradiol and 10 mg of dydrogesterone.The patients in the observation group were treated with Bushen Shugan Decoction combined with hormone supplementation for 3 menstrual cycles.The clinical efficacy and the changes of serum FSH,LH and E2 levels were observed,and the adverse drug reactions were recorded.Results:After treatment,the total effective rate of the observation group(89.47%)was significantly higher than that of the control group(68.42%),and the difference was statistically significant(P<0.05).After treatment,the sex hormone levels(FSH,LH and E2)and TCM symptom scores of the observation group were significantly better than those of the control group,and the differences were statistically significant(P<0.05,P<0.01).During the treatment,the incidence of breast swelling pain,irregular vaginal bleeding,dyspepsia and the total incidence of adverse reactions in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion:Compared with
作者
张秋仔
陈玉玲
倪凯滨
吴佳敏
黄燕芳
李宇青
郭进
Zhang Qiuzi;Chen Yuling;Ni Kaibin;Wu Jiamin;Huang Yanfang;Li Yuqing;Guo Jin(Mindong Hospital Affiliated to Fujian Medical University,Fu′an Fujian 355000)
出处
《山西中医药大学学报》
2023年第5期534-536,541,共4页
Journal of Shanxi University of Chinese Medicine
基金
福建中医药大学2022年临床专项校管科研项目(XB2022165)。
关键词
围绝经期综合征
补肾疏肝汤
激素补充
疗效
perimenopausal syndrome
Bushen Shugan Decoction
hormone supplement
therapeutic effect
