摘要
目的:观察自拟“抑瘤方”治疗成人弥漫内生型脑干胶质瘤(DIPG)的临床疗效。方法:纳入20例放弃西医治疗、自愿坚持中药治疗的成人DIPG患者,每日予“抑瘤方”配方颗粒口服,观察期1年,疗程结束后了解影像学进展情况,并进行有效率、不良反应及安全性评价。结果:1年疗程结束后,20例患者中,死亡4例,存活16例,1年生存率80%,临床稳定率40%(8/20)。结论:对于脑干胶质瘤(尤其是DIPG)这类西医无法手术、预后极差的患者,宜尽早介入中医药治疗,比单纯西医治疗更具优势。但患者长期服用中药确有困难,初诊后应密切随访,尽可能鼓励患者坚持用药。
Objective:The clinical efficacy of Yiliu Formula in the treatment of adult diffuse intrinsic pontine glioma(DIPG)was observed.Methods:Twenty adult DIPG patients who had given up western medicine treatment and voluntarily adhered to traditional Chinese medicine treatment were included.The prescription granule of Yiliu Formula was taken orally every day,and the observation period was one year.The imaging progress was understood after the course of treatment,and the effective rate,adverse reactions and safety were evaluated.Results:After one year of treatment,4 of the 20 patients died and 16 survived,with 1-year survival rate of 80%and clinical stability(SD)rate of 40%(8/20).Conclusion:For patients with brainstem glioma(especially DIPG),which cannot be operated on by western medicine and has a very poor prognosis,early intervention with traditional Chinese medicine is recommended,which is more advantageous than western medicine alone.However,it is indeed difficult for patients to take traditional Chinese medicine for a long time.Patients should be closely followed up after the initial diagnosis and encouraged to adhere to the medication as far as possible.
作者
王林
樊永平
WANG Lin;FAN Yong-ping(Department of Traditional Chinese Medicine,Beijing Tiantan Hospital,Capital Medical University,Beijing 100070,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2020年第3期1571-1573,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
首都中医药研究专项(No.17ZY01)
北京天坛医院青年科研基金(No.2017-YQN-20)。
关键词
弥漫内生型脑干胶质瘤
抑瘤方
扶正祛邪
脑瘤
健脾补肾
活血化痰
本虚标实
临床观察
Diffuse intrinsic pontine glioma
Yiliu Formula
Promoting health and expelling evil
Brain tumor
Strengthening and spleen tonifying kidney
Promoting blood circulation and reducing phlegm
Deficiency in origin and enrichment in symptom
Clinical observation
