摘要
对Ⅱ型糖尿病小鼠分别灌胃109,108 CFU/mL和107 CFU/mL副干酪乳杆菌TD062,研究其对糖尿病小鼠的降糖作用。同时检测糖原合成酶激酶-3β(GSK-3β)基因的表达情况,探讨其降糖机制。试验结果表明,副干酪乳杆菌TD062可有效改善糖尿病小鼠血糖水平、脏器指数和体重,显著提高葡萄糖耐受性及抗氧化能力,并通过降低GSK-3β的相对基因表达量,调节糖尿病模型中糖代谢紊乱,改善胰岛素抵抗,从而有效预防糖尿病的发生,为功能性食品的开发提供理论依据。
The objective of this study was to evaluate hypoglycemic effects of Lactobacillus paracasei TD062 on the type 2 diabetes mice treated with the strain at 109,108 and 107 CFU/mL.Meanwhile,the expression levels of glycogen synthase kinase 3β(GSK-3β)were determined to explore the hypoglycemic mechanism.The results demonstrated that L.paracasei TD062 could ameliorate glucose levels,organ coefficient and body weight.In addition,glucose tolerance and antioxidant capacity were elevated by oral administration of L.paracasei TD062.Furthermore,it was revealed that L.paracasei TD062 downregulated the relative expression levels of GSK-3β,regulated glucose metabolic disorders and ameliorated insulin resistance,thus delaying the development of diabetes.Therefore,L.paracasei TD062 might be applied as a new type of hypoglycemic agent in functional foods.
作者
张宇
姜毓君
党芳芳
潘瑞丽
陈思涵
林官根
张雅硕
满朝新
张微
Zhang Yu;Jiang Yujun;Dang Fangfang;Pan Ruili;Chen Sihan;Lin Guangen;Zhang Yashuo;Man Chaoxin;Zhang Wei(College of Food Science,Northeast Agricultural University,Key Laboratory of Dairy Science,Ministry of Education,Harbin 150030)
出处
《中国食品学报》
EI
CAS
CSCD
北大核心
2020年第5期106-112,共7页
Journal of Chinese Institute Of Food Science and Technology
基金
国家高层次人才特殊支持计划项目(810098)。
关键词
Ⅱ型糖尿病
副干酪乳杆菌TD062
降糖作用
type 2 diabetes mellitus
Lactobacillus paracasei TD062
hypoglycemic effect
