摘要
目的探究十八味诃子利尿丸的降糖作用。方法两种不同时间间隔的多次给药方法建立四氧嘧啶糖尿病大鼠模型,血糖测定评估造模效果;成模后,观测十八味诃子利尿丸对大鼠摄食量、饮水量、尿量、体重、血糖、胰岛素水平、己糖激酶、琥珀酸脱氢酶、超氧化物歧化酶活力、丙二醛含量的影响,评估降糖效能。结果 24 h间隔给药法造模可使血糖显著升高(P<0. 05),且符合糖尿病标准;十八味诃子利尿丸可改善糖尿病大鼠"三多一少"症状(P<0. 05),降低血糖及丙二醛含量(P<0. 05),增加己糖激酶、琥珀酸脱氢酶及超氧化物歧化酶活力(P<0. 05),提高胰岛素水平(P<0. 05)。结论 24 h间隔给药法可建立四氧嘧啶糖尿病大鼠模型;十八味诃子利尿丸具有良好的降糖效果,其机制可能与促进机体对葡萄糖的摄取利用、提高抗氧化能力、减轻胰岛的损伤关系密切。
Objective To explore the hypoglycemic effect of eighteen flavor myrobalan diuretic pills on diabetic.Methods Adopting two kinds of methods to establish diabetic rat model,the result was evaluated by measuring the level of fasting blood glucose(FBG).Then the hypoglycemic effect of eighteen flavor myrobalan diuretic pills on diabetes was evaluated by testing food intake,water intake,urinary volume,weight,and the levels of FBG,fasting insulin(FINS),hexokinase(HK),succinate dehydrogenase(SDH),superoxide dismutase(SOD),malondialdehyde(MDA)and histopathology of islet in diabetic rats.Results The level of FBG was increased significantly(P<0.05)and in accordance with the diabetic standard by adopting the administering method of 24 h interval to establish diabetic rat model.Eighteen flavor myrobalan diuretic pills decreased food intake,water intake,urinary volume,the level of FBG,the content of MDA(P<0.05);and increased weight,the level of FINS,the activities of HK,SDH,SOD(P<0.05).It also reduced islet injury.Conclusions The administering method of 24 h interval could establish diabetic rat model successfully.And eighteen flavor myrobalan diuretic pills have good hypoglycemic effect,which relates with promoting the body to use the uptake of glucose and improving antioxidant capacity to reduce islet damage.
作者
梁沛余
段路路
吴穹
LIANG Pei-Yu;DUAN Lu-Lu;WU Qiong(Graduate School of Wuhan University,Wuhan 430070,Hubei,China)
出处
《中国老年学杂志》
CAS
北大核心
2019年第1期141-144,共4页
Chinese Journal of Gerontology
基金
国家自然科学基金资助项目(81860762)
青海省2018年科技计划基础研究计划项目(2018-ZJ-721)
青海省卫生计生科研指导性计划课题(2018-wjzdx-131)
关键词
糖尿病
造模
十八味诃子利尿丸
降糖
Diabetes
Eighteen flavor myrobalan diuretic pills
Hypoglycemic
